aladdin 阿拉丁 U413745 UNC2250 1493694-70-4 Moligand?,≥99%

中文名：UNC2250

英文名：UNC2250

纯度：Moligand™，≥99%

货号：U413745

Cas号：1493694-70-4

存储温度：避光,-20°C储存,充氩

运输条件：超低温运输

产品介绍：

Information

UNC2250 UNC2250 is a potent and selective Mer inhibitor with IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

Targets

Axl ; Axl ; Mer ; Tyro3 ; 1.7 nM; 100 nM

In vitro

UNC2250 efficiently inhibits Mer phosphorylation in 697 B-ALL cells and Colo699 NSCLC cells. Moreover, UNC2250 also displays functional antitumor activity by reducing colony-forming potential in both rhabdoid tumor cells and NSCLC cells.

In vivo

According to in vivo PK experiment, UNC2250 has a moderate half-life, clearance, and volume of distribution as well as reasonable oral bioavailability and good solubility.

Cell Research(from reference)

Cell lines：BT-12 rhabdoid tumor cells, and Colo699 NSCLC cells 

Concentrations：~3 μM for BT-12, ~300 nM for Colo699 

Incubation Time：3 weeks for BT-12, 2 weeks for Colo699 

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/U413745.html