(S,R,S)-AHPC-PEG2-acid

(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker and VHL ligand designed for applications in targeted protein degradation and PROTAC development. Its structure, 3-(2-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)ethoxy)propanoic acid, contains an AHPC-derived VHL-binding moiety, a PEG2 spacer, and a terminal carboxylic acid functional group. The PEG2 segment provides a flexible spacer for connecting the VHL ligand to a target-protein ligand in the construction of heterobifunctional PROTAC molecules.

The compound has a CAS No. of 2172820-09-4, a molecular formula of C₃₀H₄₂N₄O₈S, and a molecular weight of 618.74 g/mol. The terminal carboxylic acid provides a convenient reactive handle for amide-coupling reactions with amine-containing ligands, making this compound a useful building block for the synthesis of VHL-recruiting PROTACs and related targeted protein degradation molecules.

(S,R,S)-AHPC-PEG2-acid is intended for research in medicinal chemistry, chemical biology, and targeted protein degradation. It can be incorporated into PROTAC architectures to connect a VHL E3 ubiquitin ligase ligand with a ligand targeting a protein of interest, supporting the development and investigation of compounds that utilize the ubiquitin-proteasome system for selective protein degradation.