MRTX1133原料厂家

中文名称MRTX1133中文同义词2-NAPHTHALENOL,4-[4-(3,8-DIAZABICYCLO[3.2.1]OCT-3-YL)-8-FLUORO-2-[[(2R,7AS)-2-FLUOROTETRAHYDRO-1H-;4-[4-(3,8-二氮杂双环[3.2.1]OCT-3-基)-8-氟-2-[(2R,7AS)-2-氟四氢-1H-吡咯里嗪-7A(5H)-基]甲氧基]吡啶基[4,3-D]嘧啶-7-基]-5-乙炔基-6-氟-2-萘醇;化合物MRTX1133;4-[4-[(1R,5S)-3,8-二氮杂双环[3.2.1]辛烷-3-基]-8-氟-2-[[(2S,7AS)-2-氟六氢-1H-吡呤环-7A-基]甲氧基]吡啶并[4,3-D]嘧啶-7-基]-5-乙炔基-6-氟萘-2-醇;4-[4-[(1R,5S)-3,8-二氮杂双环[3.2.1]辛烷-3-基]-8-氟-2-[[(2S,7AS)CHEMICALBOOK-2-氟六氢-1H-吡呤环-7A-基]甲氧基]吡啶并[4,3-D];4-(4-(3,8-二氮杂双环[3.2.1]辛烷-3-基)-8-氟-2-(((2R,7AS)-2-氟六氢-1H-吡咯嗪-7A-基)甲氧基)吡啶并[4,3-D]嘧啶-7-基)-5-乙炔基-6-氟萘-2-醇;4-[4-(3,8-二氮杂双环[3.2.1]辛-3-基)-8-氟-2-[[(2R,7AS)-2-氟四氢-;4-(4-(3,8-二氮杂双环[3.2.1]辛-3-基)-8-氟-2-(((2R,7AS)-2-氟六氢-1H-吡咯嗪-7A-基)甲氧基)吡啶并[4,3-D]嘧啶-7-基)-5-乙炔基-6-氟萘基-2-醇英文名称MRTX1133英文同义词2-Naphthalenol,4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-;MRTX1133;4-(4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol;4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol;KRAS,Ras,MRTX1133,G12D,cells,active,wild-type,phosphorylation,mutant,MRTX1133,inactive,ERK,inhibit,tumor,states,MRTX-1133,Inhibitor;4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-Naphthalenol;4-[4-[3,8-Diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol;Niraparib(MK-4827)tosylatemonohydrateCAS号2621928-55-8分子式C33H31F3N6O2分子量600.63

MRTX1133性质密度1.49±0.1g/cm3(Predicted)溶解度DMSO:50.0(浓度mg/mL);83.24(浓度mM)形态固体酸度系数(pKa)8.05±0.40(Predicted)颜色黄至棕色