山茱萸新苷(山茱萸裂甙)

product name: Cornuside

cas no.:131189-57-6

chemical name;Methyl (2R,3S,4R)-3-ethenyl-4-[2-(3,4,5-trihydroxybenzoyl)oxyethyl]-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate

molecular formula: C₂₄H₃₀O₁₄

molecular weight: 542.49

solubility: soluble in Pyridine, Methanol

appearance: powder

purity by hplc: >98%

biological activity:Cornuside has immunomodulatory activity; Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells; Cornuside can treat  myocardial  I/R and  protect the liver from CCl?-induced acute hepatotoxicity, by reducing oxidative stress and suppressing  inflammatory responses; Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells; Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.