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  • 曲伐沙星|T13231|TargetMol

曲伐沙星|T13231|TargetMol

Trovafloxacin
￥297 1mg 起订
￥745 5mg 起订
￥1230 10mg 起订
上海 更新日期：2026-05-09

TargetMol 中国（陶术生物）

VIP1年
联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
曲伐沙星
英文名称：
Trovafloxacin
CAS号：
147059-72-1
品牌：
TargetMol
产地：
美国
保存条件：
Store under nitrogen,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
纯度规格：
99.21%
产品类别：
抑制剂
货号：
T13231

Product Introduction

Bioactivity

名称Trovafloxacin
描述Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
体外活性In HepG2 cells, Trovafloxacin (20 μM; 24 hours; ) and tumor necrosis factor (TNF; 4 ng/mL) incubation induces apoptosis and increases leakage of lactate dehydrogenase (LDH)[1]. Trovafloxacin (20 μM; 24 hours; HepG2 cells) and TNF (4 ng/mL) incubation increases expression of early NF-κB-related factors A20 and IκBα[1]. Trovafloxacin prolongs TNF-induced activation of MAPKs and IKKα/β activation in HepG2[1]. Trovafloxacin is a potent TO-PRO-3 uptake inhibitor by apoptotic cells. Trovafloxacin also inhibits ATP release from apoptotic cells. Trovafloxacin is equally active against both penicillin-susceptible and -resistant pneumococci, with MICs of 0.06-0.25 mg/mL reported for more than 700 isolates. The MICs of Trovafloxacin at which 90% of isolates are inhibited for 55 isolates of pneumococci is 0.125 μg/mL[3].
体内活性In male C57BL/6 J mice, TNF-induced p65 nuclear translocation disrupted by Trovafloxacin (150 mg/kg; oral administration). Trovafloxacin treatment increases expression of early NF-κB-related factors A20 and IκBα[1]. Trovafloxacin increased serum levels of alanine amino transferases (ALT) and pro-inflammatory cytokines when administered in combination with lipopolysaccharide (LPS) or TNF to mice induces severe liver toxicity associated with vast apoptotic areas in the liver[1].
存储条件Store under nitrogen,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度H2O : Insoluble
DMSO : 4.17 mg/mL (10.02 mM), Sonication is recommended.
关键字Trovafloxacin | topoisomerase-IV | Topoisomerase | TNF | pro-inflammatory | pneumococci | PANX1 | Pannexin 1 channel (PANX1) | NF-κB | LPS | Inhibitor | inhibit | hepatotoxicity | gyrase | DNAgyrase | DNA gyrase | DNA | broad-spectrum | bacterial | Antibiotic
相关产品Adipic dihydrazide | Levulinic acid | Doxycycline | Neomycin sulfate | Terbinafine hydrochloride | BES | Dimethyl sulfoxide | Sodium bicarbonate | Hyaluronic acid sodium (MW 20 kDa) | Sodium diacetate | Sulfamethoxazole sodium | D(+)-Raffinose pentahydrate
相关库经典已知活性库 | 已知活性化合物库 | 肝脏毒性化合物库 | 抗菌活性库 | 抗感染化合物库 | 含氟化合物库 | FDA上市及药典收录分子库 | FDA 上市药物库 | DNA 损伤和修复分子库 | 口服活性化合物库 | 药物功能重定位化合物库 | 人代谢物化合物库
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曲伐沙星|TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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