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  • 化合物 BMY 45778|T21947|TargetMol

化合物 BMY 45778|T21947|TargetMol

BMY 45778
￥373 1mg 起订
￥918 5mg 起订
￥1450 10mg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
化合物 BMY 45778
英文名称：
BMY 45778
CAS号：
152575-66-1
品牌：
TargetMol
产地：
美国
保存条件：
Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
纯度规格：
98.53%
产品类别：
抑制剂
货号：
T21947

Product Introduction

Bioactivity

名称BMY 45778
描述BMY 45778 is a potent non-prostaglandin-like prostaglandin partial agonist that inhibits platelet aggregation in humans, rabbits, and mice, with IC50s of 35 nM, 136 nM, and 1.3 μm, respectively.BMY 45778 acts by stimulating prostacyclin receptors.
体外活性BMY 45778 inhibits human (IC50 = 35 nM), rabbit (136 nM), and rat (1.3 microM) platelet aggregation. This compound activates adenylyl cyclase (ED50 = 6-10 nM) and stimulates GTPase in human platelet membrane preparations. The potency (EC50) of BMY 45778 stimulating adenylyl cyclase is comparable to iloprost. However, maximal stimulation of GTPase by BMY 45778 is approximately half the iloprost-stimulated activity, and BMY 45778 limits the GTPase stimulation by iloprost suggesting that BMY 45778 is a partial agonist at the IP receptor. BMY 45778 completely prevents [3H]]Iloprost binding to platelet membranes (IC50 = 7 nM). In whole platelets, BMY 45778 causes elevation of platelet cAMP levels (cAMP content doubles at 13 nM) and activation of the cAMP-dependent protein kinase (cAMP-protein kinase ratio is twice basal at 2 nM). BMY 45778 treatment of whole platelets also desensitizes the adenylyl cyclase activation by iloprost. These results indicate that BMY 45778, which is structurally different from prostacyclin and most prostacyclin agonists, acts by stimulating prostacyclin (IP) receptors.[1]
存储条件Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
关键字Prostacyclin receptor
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BMY-45778|TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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