葫芦巴碱 新品

Trigonelline

White to off-white crystalline powder, odorless or with a slightly special smell；

Trigonelline regulates the balance of glycolipid metabolism through multiple pathways:

Improve insulin sensitivity and β -cell function

Activate PPARγ (peroxisome proliferator-activated receptor γ) to enhance insulin sensitivity

Inhibit GSK-3 (glycogen synthase kinase-3) and promote glycogen synthesis

Reduce the expression of caspase-3, inhibit β -cell apoptosis, and protect pancreatic islet function

(2) Regulate enzymes related to sugar metabolism

Reduce the expression of glucose-6-phosphatase (G6pc) and glucose transporter 2 (Slc2a2), and inhibit hepatic gluconeogenesis

Regulate the expression of glucose transporter 4 (Glut4) and promote glucose uptake in peripheral tissues

(3) Regulate lipid metabolism

Inhibit the expression of fatty acid synthase (FAS) and PPARγ, and reduce adipocyte differentiation and lipid accumulation

It promotes the oxidation and lipolysis of fatty acids and has the potential to prevent obesity