血管紧张素II受体1型激动剂多肽TRV-120027/1234510-46-3/TRV-120027 新品

Product Name：TRV-120027

CAS No.：1234510-46-3

Synonyms：血管紧张素II受体1型激动剂多肽TRV-120027

Catalog No.：218P125

Brand：Typeptide Biotech（肽研生物）

Description：TRV-120027是血管紧张素 II 受体 1 型 (AT1R) 的β-arrestin-1激动剂多肽，多肽序列中含有8个氨基酸，可通过阳离子通道亚家族 C3 (TRPC3) 偶联诱导急性儿茶酚胺分泌，促进质膜上 AT1R-β-arrestin-1-TRPC3-PLCγ 形成大分子复合物。抑制血管紧张素 II 介导的血管收缩并增加心肌细胞的收缩力。有潜力用于急性失代偿性心力衰竭 (ADHF) 的研究。

TRV-120027 is a β-arrestin-1 agonist peptide targeting the angiotensin II receptor type 1 (AT1R), consisting of an 8-amino acid sequence. It induces acute catecholamine secretion via coupling with the TRPC3 subfamily of cation channels, promoting the formation of a macromolecular complex on the plasma membrane—AT1R-β-arrestin-1-TRPC3-PLCγ. This peptide inhibits angiotensin II-mediated vasoconstriction and enhances myocardial contractility, showing potential for research in acute decompensated heart failure (ADHF).

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

南京肽研生物生物科技有限公司

手机号：19961912513(微信同号)

QQ: 2178255659

邮箱：sales@typeptide.com

联系人：顾经理

申明：本产品仅供科研使用，不得用于人体。