血管紧张素II受体1型激动剂多肽TRV-120027/1234510-46-3

Product Name：TRV-120027

CAS No.：1234510-46-3

Synonyms：血管紧张素II受体1型激动剂多肽TRV-120027

Catalog No.：218P125

Brand：HongTide（上海鸿肽生物）

Description：TRV-120027是血管紧张素 II 受体 1 型 (AT1R) 的β-arrestin-1激动剂多肽，多肽序列中含有8个氨基酸，可通过阳离子通道亚家族 C3 (TRPC3) 偶联诱导急性儿茶酚胺分泌，促进质膜上 AT1R-β-arrestin-1-TRPC3-PLCγ 形成大分子复合物。抑制血管紧张素 II 介导的血管收缩并增加心肌细胞的收缩力。有潜力用于急性失代偿性心力衰竭 (ADHF) 的研究。

TRV-120027 is a type of angiotensin II receptor 1 (AT1R) β- Arrestin-1 agonist peptide, containing 8 amino acids in the peptide sequence, can induce acute catecholamine secretion through the coupling of cationic channel subfamily C3 (TRPC3), promoting AT1R on the plasma membrane- β- arrestin-1-TRPC3-PLC γ  Forming macromolecular complexes. Inhibiting angiotensin II mediated vasoconstriction and increasing the contractility of myocardial cells. There is potential for research on acute decompensated heart failure (ADHF).

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

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