人Tau / 2N4R蛋白, Tag Free, low endotoxin

Human Tau-441 / 2N4R Protein, Tag Free, low endotoxin (MALS verified)

分子别名（Synonym）

DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU

表达区间及表达系统（Source）

Human Tau-441, Tag Free (TAU-H5117) is expressed from E. coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8).

Predicted N-terminus: Met 1

蛋白结构（Molecular Characterization）

This protein carries no "tag".

The protein has a calculated MW of 45.8 kDa. The protein migrates as 30-53 kDa and 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

内毒素（Endotoxin）

Less than 0.01 EU per μg by the LAL method / rFC method.

无菌（Sterility）

Negative

纯度（Purity）

>90% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

制剂（Formulation）

Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

The product MUST be stored at -70°C or lower upon receipt;

-70°C for 3 months under sterile conditions.

背景介绍

Tau蛋白是一种微管相关蛋白，由位于17号染色体长臂21区（17q21）的MAPT基因编码。该蛋白具有促进微管组装和稳定性的功能，并可能参与神经元极性的建立与维持。Tau蛋白的过度磷酸化（形成tau包涵体，即pTau）可导致配对螺旋细丝和直细丝的自发性缠结，这种缠结与阿尔茨海默病、额颞叶痴呆及其他tau蛋白病的发病机制密切相关。