Phospho-OXSR1 (Thr185)抗体;Phospho-OXSR1 (Thr185) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-OXSR1 (Thr185) in HepG2 lysates using Phospho-OXSR1 (Thr185) antibody.    

  
  

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     Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue using OSR1 (Phospho-Thr185) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.    

  
  

The Phospho-OXSR1 (Thr185) antibody is a specialized tool used to detect the phosphorylated form of OXSR1 (Oxidative Stress Response 1) at threonine 185. a critical post-translational modification linked to its activation. OXSR1. a serine/threonine kinase belonging to the STE20 family, plays a pivotal role in cellular responses to oxidative stress and osmotic pressure. It regulates ion transport and cell volume by phosphorylating downstream targets like the Na⁺/K⁺/2Cl⁻ cotransporter NKCC1. Phosphorylation at Thr185 is essential for OXSR1 kinase activity, triggered by stress-activated signals such as p38 MAPK pathway activation. This modification induces conformational changes, enabling OXSR1 to interact with and phosphorylate its substrates, thereby maintaining cellular homeostasis under stress conditions.

The Phospho-OXSR1 (Thr185) antibody is widely used in research to study OXSR1 activation dynamics in models of oxidative stress, inflammation, and metabolic disorders. It aids in elucidating mechanisms underlying diseases like hypertension, cancer, and neurodegenerative conditions, where dysregulated stress signaling is implicated. Validated in techniques like Western blotting, immunofluorescence, and immunoprecipitation, this antibody ensures specificity for the phosphorylated epitope, distinguishing active OXSR1 from its inactive form. Its application enhances understanding of stress-responsive pathways and potential therapeutic targets, making it a valuable tool in molecular and cellular biology research.