盐酸RGX-104|T5128|TargetMol

RGX-104 hydrochloride
610318-03-1

￥343 1mg 起订

￥496 2mg 起订

￥993 5mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

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联系人：邵小姐

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邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 盐酸RGX-104

英文名称：: RGX-104 hydrochloride

CAS号：: 610318-03-1

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.06%

产品类别：: 抑制剂

货号：: T5128

Product Introduction

Bioactivity

名称	RGX-104 hydrochloride
描述	RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene.
细胞实验	Myeloid-derived suppressor cells were isolated as previously described from splenic tissue of tumor-bearing mice. One hundred thousand cells were plated in quadruplicates in poly-L-lysine coated plates. After 3 hours of treatment with 1uM RGX-104 or DMSO as vehicle, cells were fixed with 4% PFA for 15 minutes and wash 3 times with 1X PBS prior staining. Rabbit monoclonal anti-Ki67 antibody (1:400 dilution) was applied at 4C overnight. Cells were incubated with Alexa Fluor 488 secondary antibody (1:200 dilution) for one hour at room temperature, counterstained with DAPI (1:1000 dilution) and mounted with Prolong Gold. For the analysis of the percentage of Ki67 positive cells, five fields from each replicate were imaged at 20x magnification using Zeiss Axio Imager fluorescence microscope.
动物实验	For MDSC adoptive transfer experiments into tumor-bearing mice, 2 × 10^6 MDSCs were isolated as described above from C57BL/6 tumor-bearing mice and subsequently labeled with BD Horizon Violet (BV) Proliferation Dye and then adoptively transferred via retro-orbital injection into wild-type mice. Mice were then treated with RGX-104 (100 mg/kg/day) or control diet for 36 hours. Spleens of recipient mice were then harvested and processed for flow cytometry analysis as described above. For MDSC adoptive transfer experiments in to WT and ApoE?/? non-tumor bearing mice, 5 × 10^6 MDSCs were isolated as described above from tumor-bearing mice (either wild-type C57BL/6 or Apoe?/? mice) and subsequently labeled with BV cell tracker dye and then adoptively transferred via retro-orbital injection into either wild-type or Apoe?/? mice. Mice were then treated with GW3965 (100 mg/kg/day) or control diet for 48 hours. Spleens of recipient mice were then harvested and processed for flow cytometry analysis.
体内活性	通过口服给予动物RGX-104显著抑制了多种癌症类型的可触及肿瘤生长。在携带大型肿瘤的动物中，也观察到强烈的肿瘤生长抑制作用。与对照组相比，经过8天的治疗后，以RGX-104（100 mg/kg）处理的小鼠中，总CD45+淋巴细胞中凋亡性循环G-MDSCs显著增加。
存储条件	keep away from direct sunlight,keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 115 mg/mL (181.81 mM), Sonication is recommended.
关键字	SB-742881 \| SB 742881 \| RGX-104 Hydrochloride \| RGX104 hydrochloride \| RGX104 Hydrochloride \| RGX-104 \| RGX104 \| RGX 104 hydrochloride \| RGX 104 Hydrochloride \| RGX 104 \| LXR \| LiverXReceptor \| Liver X receptor \| Liver X Receptor \| Inhibitor \| inhibit
相关产品	SR9243 \| (20S)-Protopanaxatriol \| T0901317 \| GW6340 \| Rovazolac \| GSK2033 \| SR9238 \| RGX-104 \| LXR-623 \| GW3965 hydrochloride \| BE1218 \| GAC0003A4
相关库	抗癌活性化合物库 \| NO PAINS 化合物库 \| 血液病分子库 \| 核受体化合物库 \| 临床期小分子药物库 \| 口服活性化合物库 \| 抗代谢疾病化合物库 \| 抗癌临床化合物库 \| 抗癌药物库

盐酸RGX-104|||SB742881|||RGX-104 HCl|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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