FOXP1 抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10871(FOXP1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10871(FOXP1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The FOXP1 antibody is a crucial tool in studying the FOXP1 protein, a member of the Forkhead box (FOX) transcription factor family. FOXP1 plays vital roles in embryonic development, immune regulation, and tissue differentiation, particularly in the brain, heart, and lungs. It acts as a transcriptional repressor, modulating gene expression by binding to DNA. Dysregulation of FOXP1 is linked to developmental disorders, intellectual disabilities, and cancers, including lymphomas and solid tumors.

FOXP1 antibodies are widely used in research to detect and quantify FOXP1 expression via techniques like immunohistochemistry (IHC), Western blotting, and flow cytometry. In cancer studies, these antibodies help assess FOXP1's role as an oncogene or tumor suppressor, depending on context. For example, FOXP1 overexpression in diffuse large B-cell lymphoma correlates with poor prognosis, while its loss in some carcinomas may drive metastasis.

Clinically, FOXP1 antibodies aid in diagnosing B-cell malignancies, where FOXP1 expression helps differentiate subtypes. They also contribute to understanding FOXP1's interaction with other proteins (e.g., FOXP2/FOXP3) in immune pathways. Challenges include cross-reactivity with related FOX proteins, necessitating rigorous validation. Ongoing research explores FOXP1-targeted therapies, emphasizing the antibody's continued importance in translational medicine.