FOXP1抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using FOXP1 mouse mAb against HeLa (1), Jurkat (2), MCF-7 (3), T47D (4), and Raw264.7 (5) cell lysate.    

  
  

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     Flow cytometric analysis of Jurkat cells using FOXP1 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using FOXP1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using FOXP1 mouse mAb with DAB staining.    

  
  

The FOXP1 antibody is a crucial tool in studying the FOXP1 protein, a member of the forkhead box (FOX) protein family, which functions as a transcriptional regulator. FOXP1 plays vital roles in embryonic development, immune system regulation, and tissue-specific gene expression. It is particularly important in the development of organs such as the brain, heart, and lungs, as well as in B-cell differentiation. Dysregulation of FOXP1 has been linked to cancers (e.g., diffuse large B-cell lymphoma, lung adenocarcinoma), neurodevelopmental disorders (e.g., autism, intellectual disability), and speech/language impairments.

FOXP1 antibodies are widely used in research to detect and quantify FOXP1 protein levels via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate FOXP1's role in gene networks, its interaction with other FOX proteins (e.g., FOXP2. FOXP4), and its dual oncogenic or tumor-suppressive functions depending on cellular context. Additionally, FOXP1 antibodies aid in studying its structural features, such as the conserved forkhead DNA-binding domain and transcriptional repression motifs.

Clinically, FOXP1 antibodies serve as biomarkers for diagnosing FOXP1-related syndromes and cancers. However, antibody specificity remains a challenge due to protein isoforms and homology within the FOX family. Ongoing research focuses on optimizing antibody validation and exploring therapeutic strategies targeting FOXP1 pathways.