TSPAN16抗体;TSPAN16 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Jurkat cells using TSPAN16 mouse mAb (green) and negative control (red).    

  
  

**Background of TSPAN16 Antibody**

TSPAN16 (Tetraspanin-16) is a member of the tetraspanin family, a group of transmembrane proteins involved in organizing membrane microdomains and mediating cell-cell interactions, signaling, and adhesion. Tetraspanins are characterized by four transmembrane domains, forming complexes with integrins, receptors, and other tetraspanins to regulate cellular processes like proliferation, migration, and differentiation. TSPAN16. encoded by the *TSPAN16* gene, is less characterized compared to other tetraspanins but is implicated in cancer, immune regulation, and neurological functions.

TSPAN16 antibodies are tools used to detect and study the expression, localization, and function of TSPAN16 in biological samples. These antibodies are essential for techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry. Research suggests TSPAN16 may influence tumor progression, as altered expression has been observed in certain cancers, potentially affecting metastasis or therapeutic resistance. Additionally, TSPAN16’s role in membrane organization could link it to viral entry mechanisms, as tetraspanins often interact with pathogens.

Developing specific and validated TSPAN16 antibodies is critical for elucidating its biological roles and exploring its potential as a diagnostic marker or therapeutic target. Commercial antibodies vary in clonality (monoclonal/polyclonal), species reactivity, and applications, requiring careful validation for experimental accuracy. Ongoing studies aim to clarify TSPAN16’s interactions and contributions to disease pathways, highlighting its emerging significance in biomedical research.