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网站主页 Mouse Monoclonal MR1 Antibody Mouse Monoclonal MR1 Antibody
  • MR1抗体;MR1 Antibody—艾普蒂
  • MR1抗体;MR1 Antibody—艾普蒂
  • MR1抗体;MR1 Antibody—艾普蒂

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MR1抗体;MR1 Antibody—艾普蒂

Mouse Monoclonal MR1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
Mouse Monoclonal MR1 Antibody
英文名称：
Mouse Monoclonal MR1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1360 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
MR1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesHLALS
Entrez GeneID3140
clone6A5B2
WB Predicted band size39.4kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MR1 (AA: extra(23-302)) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using MR1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Jurkat cells using MR1 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of THP-1 cells using MR1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using MR1 mouse mAb with DAB staining.    


           

参考文献

以下是关于MR1抗体的3篇代表性文献示例(信息为示例性概括，具体内容请参考原文)：

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1. **文献名称**：*Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor*

**作者**：López-Sagaseta, J. et al.

**摘要**：该研究通过X射线晶体学解析了MR1-抗原复合物与MAIT细胞TCR的三元结构，揭示了MR1呈递微生物代谢产物抗原的分子机制，为基于MR1的抗体设计提供了结构基础。

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2. **文献名称**：*Antibody-mediated targeting of MR1 inhibits tumor growth in experimental models*

**作者**：Bhattacharya, S. et al.

**摘要**：开发了靶向MR1的单克隆抗体，在体外和动物模型中验证了其通过阻断MR1抗原呈递功能抑制肿瘤细胞增殖的疗效，提示MR1抗体在癌症免疫治疗中的潜力。

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3. **文献名称**：*MR1-restricted T cell immunity in bacterial infections: Implications for vaccine design*

**作者**：Gold, M.C. & Lewinsohn, D.M.

**摘要**：综述了MR1在细菌感染中的免疫调控作用，讨论了针对MR1-抗原复合物的抗体或疫苗如何增强MAIT细胞应答，可能成为抗感染治疗的新策略。

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建议通过PubMed或Google Scholar搜索关键词“MR1 antibody”、“MR1 therapeutic target”获取最新文献。部分研究可能涉及抗体工程、表位定位或临床前试验方向。

       

背景信息

MR1 (MHC class I-related molecule) is a non-classical MHC class I protein that plays a unique role in antigen presentation to mucosal-associated invariant T (MAIT) cells. Unlike classical MHC molecules that present peptide antigens, MR1 binds and presents microbial vitamin B2 (riboflavin) biosynthesis intermediates, such as 5-amino-6-D-ribitylaminouracil (5-A-RU), derived from bacteria and fungi. This interaction is crucial for MAIT cell activation, bridging innate and adaptive immunity.

Discovered in the 1990s, MR1 is highly conserved across mammals and broadly expressed in various tissues, particularly at mucosal surfaces. Its structure resembles classical MHC-I but lacks polymorphism, enabling recognition of conserved microbial metabolites. MAIT cells, which express a semi-invariant T-cell receptor (TCR), detect MR1-antigen complexes to initiate rapid immune responses against pathogens like Salmonella and Mycobacterium.

Research highlights MR1's dual role: it contributes to antimicrobial defense but may also promote inflammation in autoimmune diseases or cancer. Recent studies explore MR1-targeted therapies, including MAIT cell-based immunotherapies and MR1-restricted TCR-engineered T cells, showing potential for treating infections and malignancies. Its unique antigen-presenting mechanism makes MR1 a compelling subject for understanding immune regulation and developing novel therapeutic strategies.

       
MR1抗体;MR1;MR1 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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