ARG1抗体;ARG1 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)    

  
  

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     Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using ARG1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using ARG1 mouse mAb with DAB staining.    

  
  

The ARG1 antibody targets arginase 1. a metabolic enzyme encoded by the *ARG1* gene, which plays a critical role in the urea cycle by catalyzing the hydrolysis of arginine to ornithine and urea. Primarily expressed in the liver, ARG1 is essential for detoxifying ammonia and maintaining nitrogen homeostasis. Beyond hepatic function, ARG1 is also found in immune cells, such as macrophages and myeloid-derived suppressor cells (MDSCs), where it modulates immune responses by depleting arginine, a nutrient vital for T-cell activation and proliferation. This dual role links ARG1 to both metabolic disorders and immune regulation, particularly in cancer, chronic inflammation, and infectious diseases.

ARG1 antibodies are widely used in research to study enzyme expression, localization, and function across tissues and cell types. They are employed in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate ARG1's involvement in liver pathologies (e.g., cirrhosis, urea cycle disorders) and its immunosuppressive effects in tumor microenvironments. Additionally, ARG1 antibodies serve as tools for exploring therapeutic strategies, such as blocking ARG1 activity to enhance antitumor immunity. When selecting an ARG1 antibody, factors like species reactivity, validation in specific applications, and compatibility with experimental models are crucial to ensure reliability. Commercial antibodies are often validated using knockout controls or enzymatic assays to confirm specificity, given the enzyme's structural similarity to arginase 2 (ARG2).