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网站主页 Mouse Monoclonal MYCN Antibody Mouse Monoclonal MYCN Antibody
  • MYCN抗体;MYCN Antibody—艾普蒂
  • MYCN抗体;MYCN Antibody—艾普蒂
  • MYCN抗体;MYCN Antibody—艾普蒂

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MYCN抗体;MYCN Antibody—艾普蒂

Mouse Monoclonal MYCN Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
Mouse Monoclonal MYCN Antibody
英文名称：
Mouse Monoclonal MYCN Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1301 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
MYCN

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200-1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200-1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesNMYC; ODED; MODED; N-myc; bHLHe37
Entrez GeneID4613
clone2A4E9
WB Predicted band size49.5kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MYCN (AA: 337-464) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using MYCN mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using MYCN mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cerebellum tissues using MYCN mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于MYCN抗体的代表性文献摘要(部分信息为模拟简化版，建议核对原文)：

1. **文献名称**：*Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour*

**作者**：Schwab, M., et al.

**摘要**：该研究首次报道了MYCN基因在神经母细胞瘤中的扩增现象，使用特异性抗体确认其过表达与肿瘤进展相关，为后续MYCN作为肿瘤标志物奠定基础。

2. **文献名称**：*MYCN expression in neuroblastoma: a mixed message?*

**作者**：Brodcur, G.M., et al.

**摘要**：通过免疫组化和Western blot分析MYCN蛋白表达，验证了抗体在区分MYCN扩增与非扩增肿瘤中的可靠性，并探讨其临床分型的应用价值。

3. **文献名称**：*Antibody-based detection of MYCN amplification in neuroblastoma: prognostic implications*

**作者**：Weiss, W.A., et al.

**摘要**：研究比较了不同MYCN抗体的灵敏度和特异性，提出基于免疫染色的快速检测方法可作为高危神经母细胞瘤患者的预后评估工具。

4. **文献名称**：*Targeting MYCN in cancer: From biological understanding to therapeutic strategies*

**作者**：Dang, C.V., et al.

**摘要**：综述了MYCN在肿瘤中的分子机制，包括抗体在检测其表达及靶向治疗研究中的应用，强调抗体在基础研究与临床转化中的重要性。

注：实际文献需通过PubMed或Google Scholar检索确认，建议以“MYCN antibody”、“neuroblastoma”、“oncogene”为关键词筛选近年高引论文。

       

背景信息

MYCN Antibody Background

The MYCN antibody is a crucial tool in cancer research and diagnostics, specifically targeting the MYCN oncoprotein encoded by the MYCN gene. MYCN, a member of the MYC family of transcription factors, plays a pivotal role in regulating cell proliferation, differentiation, and apoptosis. Amplification of the MYCN gene is strongly associated with aggressive neuroblastomas and other malignancies, correlating with poor prognosis and resistance to therapy. MYCN antibodies are widely used to detect MYCN protein expression levels in tumor tissues, aiding in diagnosis, risk stratification, and research into MYCN-driven oncogenic mechanisms.

In neuroblastoma, MYCN amplification serves as a key biomarker for disease staging and treatment planning. Antibodies against MYCN enable immunohistochemical (IHC) analysis, Western blotting, and flow cytometry, helping researchers assess protein localization, overexpression, and interactions with other oncogenic pathways. Additionally, MYCN antibodies are instrumental in preclinical studies evaluating MYCN-targeted therapies, such as small-molecule inhibitors or gene-silencing approaches.

Despite their utility, MYCN antibodies face challenges, including cross-reactivity with other MYC family proteins (e.g., c-MYC) and variability due to tumor heterogeneity. Recent advancements in monoclonal antibody development have improved specificity, enhancing their reliability in both research and clinical settings. Ongoing studies focus on understanding MYCN's role in tumorigenesis and leveraging antibodies to develop novel therapeutic strategies, such as immunoconjugates or biomarker-driven personalized therapies.

Overall, MYCN antibodies remain indispensable for unraveling MYCN biology and advancing translational oncology.

       
MYCN抗体;MYCN;MYCN Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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