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网站主页 Mouse Monoclonal CNN3 Antibody Mouse Monoclonal CNN3 Antibody
  • CNN3抗体;CNN3 Antibody—艾普蒂
  • CNN3抗体;CNN3 Antibody—艾普蒂
  • CNN3抗体;CNN3 Antibody—艾普蒂

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CNN3抗体;CNN3 Antibody—艾普蒂

Mouse Monoclonal CNN3 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
Mouse Monoclonal CNN3 Antibody
英文名称：
Mouse Monoclonal CNN3 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1268 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CNN3

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/500 - 1/2000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

Entrez GeneID1266
clone5E4E4
WB Predicted band size36.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CNN3 (AA: 26-130) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using CNN3 mouse mAb against Hela (1), U251 (2), and HEK293 (3) cell lysate.    


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       Immunofluorescence analysis of Hela cells using CNN3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using CNN3 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CNN3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CNN3 mouse mAb with DAB staining.    


           

参考文献

以下是关于CNN3抗体的参考文献示例(仅供参考，具体文献需通过学术数据库核实)：

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1. **文献名称**：*"Calponin 3 (CNN3) as a Novel Biomarker in Gastric Cancer: Immunohistochemical Analysis Using a Specific Monoclonal Antibody"*

**作者**：Zhang L, et al.

**摘要**：本研究开发了一种针对CNN3蛋白的单克隆抗体，并通过免疫组化分析发现CNN3在胃癌组织中的高表达与肿瘤侵袭和转移显著相关，提示其可能作为预后标志物。

2. **文献名称**：*"Functional Characterization of CNN3 in Smooth Muscle Cell Contraction via Antibody-Mediated Knockdown"*

**作者**：Tanaka K, et al.

**摘要**：利用特异性CNN3抗体进行功能研究，发现抑制CNN3表达可显著降低血管平滑肌细胞的收缩能力，表明其在调节细胞骨架动力学中的关键作用。

3. **文献名称**：*"Development and Validation of a Polyclonal Antibody for Detecting CNN3 in Human Tissue Samples"*

**作者**：Wang Y, et al.

**摘要**：报道了一种高亲和力的CNN3多克隆抗体的制备，并通过Western blot和免疫荧光验证其在多种组织中的特异性，为后续疾病机制研究提供工具。

4. **文献名称**：*"CNN3 Expression Correlates with Poor Prognosis in Triple-Negative Breast Cancer: Insights from Antibody-Based Proteomic Profiling"*

**作者**：Gupta S, et al.

**摘要**：通过抗CNN3抗体对三阴性乳腺癌样本进行蛋白表达分析，发现CNN3高表达与患者生存率下降相关，提示其作为潜在治疗靶点。

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**提示**：以上为示例文献，实际研究中请通过PubMed、Web of Science等平台以“CNN3 antibody”“Calponin 3”等关键词检索最新文献，并关注抗体应用的具体场景(如疾病模型、分子机制等)。

       

背景信息

CNN3 antibody targets calponin-3 (CNN3), a member of the calponin family of actin-binding proteins involved in cytoskeletal regulation. Calponin-3. encoded by the *CNN3* gene, is expressed in smooth muscle cells, fibroblasts, and certain non-muscle tissues, where it modulates cell contraction, motility, and mechanotransduction. Unlike its isoforms CNN1 and CNN2. CNN3 exhibits broader tissue distribution and dynamic roles in cellular processes such as differentiation, adhesion, and wound healing. It interacts with actin filaments, myosin, and other cytoskeletal components, influencing cell morphology and mechanical properties.

Antibodies against CNN3 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate CNN3’s involvement in diseases such as cancer (e.g., tumor metastasis), cardiovascular disorders, and fibrotic conditions. Researchers also utilize CNN3 antibodies to explore its regulatory mechanisms in smooth muscle plasticity and tissue remodeling. Commercial CNN3 antibodies are typically raised in rabbits or mice, with specificity validated via knockout controls or siRNA silencing. Variations in antibody performance may arise due to post-translational modifications or tissue-specific isoforms, necessitating careful validation for experimental accuracy.

       
CNN3抗体;CNN3;CNN3 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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