NIT1抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta tissue, Human fetal liver tissue, Primary antibody: P08567(NIT1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08567(NIT1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08567(NIT1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The NIT1 antibody is designed to target the Nitrilase 1 (NIT1) enzyme, a member of the nitrilase superfamily involved in hydrolyzing nitrile compounds into carboxylic acids and ammonia. NIT1 is ubiquitously expressed in human tissues and plays a role in cellular detoxification, metabolism, and potentially in cancer biology. Studies suggest NIT1 may act as a tumor suppressor or promoter depending on context, with links to apoptosis regulation, DNA repair, and cell proliferation. Dysregulation of NIT1 has been observed in cancers such as hepatocellular carcinoma and colorectal cancer, though its precise mechanisms remain under investigation.

NIT1 antibodies are primarily used as research tools to detect NIT1 protein expression and localization in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies aid in elucidating NIT1's physiological and pathological roles, particularly its dual functions in tumorigenesis. Commercially available antibodies are typically validated for specificity, often targeting conserved epitopes across species. Recent interest in NIT1 antibodies extends to exploring their diagnostic or therapeutic potential, as NIT1's interaction with oncogenic pathways (e.g., p53. Wnt/β-catenin) positions it as a possible biomarker or target for cancer intervention. However, further validation is required to translate these findings into clinical applications.