XAB2抗体—艾普蒂

The XAB2 (XPA-binding protein 2) antibody is a tool used to study the multifunctional protein XAB2. which plays critical roles in transcription-coupled DNA repair (TCR), pre-mRNA splicing, and transcription regulation. XAB2. also known as SYF1 or HCNP, is part of the spliceosome-associated SYF complex and interacts with RNA polymerase II (RNAPII), facilitating coordination between transcription and DNA repair. It contains conserved domains, including TPR repeats, which mediate protein-protein interactions. In TCR, XAB2 helps recruit nucleotide excision repair (NER) factors, such as XPA, to sites of DNA damage stalled during transcription. XAB2 antibodies are essential for detecting its expression, localization, and interactions in studies exploring genome stability, transcription-coupled repair mechanisms, and spliceosome dynamics. Dysregulation of XAB2 is linked to developmental defects and diseases like cancer, making its antibody valuable for both basic research and clinical investigations. These antibodies are used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to dissect XAB2's roles in cellular pathways and disease contexts.