HSF4 抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P05698(HSF4 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The Heat Shock Factor 4 (HSF4) antibody is a critical tool for studying the HSF4 protein, a member of the heat shock transcription factor (HSF) family involved in stress response and proteostasis. HSF4 regulates the expression of heat shock proteins (HSPs), particularly in tissues like the lens, brain, and testes. Unlike other HSFs, HSF4 exists in two splice variants, HSF4a (repressor) and HSF4b (activator), which differentially modulate gene expression. Mutations in HSF4 are linked to congenital cataracts due to its role in maintaining lens transparency, and dysregulation is implicated in cancers, neurodegenerative diseases, and developmental disorders.

HSF4 antibodies enable the detection and localization of HSF4 isoforms in experimental models, aiding research into its molecular mechanisms. They are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study HSF4 expression, post-translational modifications, and interactions with co-regulators (e.g., HSP70). These antibodies also help explore HSF4’s dual role in tumorigenesis—acting as either an oncogene or tumor suppressor, depending on context. Additionally, they facilitate investigations into HSF4’s involvement in mitigating proteotoxic stress and its crosstalk with signaling pathways like NF-κB. Validated HSF4 antibodies are essential for advancing therapeutic strategies targeting HSF4-related pathologies.