HSF4抗体

The HSF4 (Heat Shock Factor 4) antibody is a tool used to detect and study the HSF4 protein, a member of the heat shock transcription factor family. HSF4 regulates the expression of heat shock proteins (HSPs), which act as molecular chaperones to protect cells under stress conditions like heat, toxins, or disease. Unlike other HSFs (e.g., HSF1. HSF2), HSF4 is constitutively active and primarily expressed in tissues such as the lens, brain, and heart. It plays a critical role in development, particularly in maintaining lens transparency; mutations in HSF4 are linked to congenital cataracts in humans. HSF4 exists in two splice variants, HSF4a and HSF4b, which exhibit opposing regulatory effects on target genes. The HSF4 antibody enables researchers to investigate its expression, localization, and function in cellular stress responses, tissue development, and disease models. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore HSF4's role in pathologies, including cataracts, cancer, and neurodegenerative disorders. This antibody has become essential for understanding HSF4's unique mechanisms in balancing proteostasis and cellular health.