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LAMP1抗体—艾普蒂

Mouse Monoclonal LAMP1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-16

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
LAMP1抗体
英文名称：
Mouse Monoclonal LAMP1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1487 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
LAMP1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesLAMPA; CD107a; LGP120
Entrez GeneID3916
clone4D2A6
WB Predicted band size44.9kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human LAMP1 (AA: 182-414) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Hek293 cells using LAMP1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human kidney tissues using LAMP1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cerebellum tissues using LAMP1 mouse mAb with DAB staining.    


           

参考文献

以下是3篇涉及LAMP1抗体的文献摘要概括：

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1. **文献名称**：*LAMP-1 and LAMP-2: Their role in autophagy and lysosomal biogenesis*

**作者**：Eskelinen EL et al.

**摘要**：该研究利用LAMP1抗体通过免疫荧光和免疫电镜技术，证实LAMP1是溶酶体膜的关键标记蛋白，并揭示其与自噬体-溶酶体融合过程的关联，为溶酶体功能研究提供方法学基础。

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2. **文献名称**：*Lysosomal membrane proteins and their central role in physiology*

**作者**：Saftig P, Klumperman J

**摘要**：通过LAMP1抗体的Western blot和共聚焦显微镜分析，作者发现LAMP1在维持溶酶体结构稳定性和细胞应激响应中的关键作用，并揭示其缺陷与神经退行性疾病的潜在联系。

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3. **文献名称**：*TFEB regulates lysosomal positioning by modulating LAMP1-mediated microtubule anchoring*

**作者**：Settembre C et al.

**摘要**：研究使用LAMP1抗体进行免疫沉淀和活细胞成像，证明LAMP1通过与微管结合蛋白相互作用调控溶酶体在细胞内的动态分布，进一步解析了溶酶体运动性的分子机制。

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4. **文献名称**：*LAMP1 controls SARS-CoV-2 entry via regulation of viral receptor ACE2 degradation*

**作者**：Chen J et al.

**摘要**：通过LAMP1抗体的流式细胞术和免疫组化分析，该文献提出LAMP1通过介导ACE2受体的溶酶体降解影响病毒入侵效率，为抗病毒治疗提供新靶点。

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以上文献均以LAMP1抗体为工具，涵盖基础机制(溶酶体动态、自噬)和疾病研究(病毒感染)，反映了其在多领域的应用价值。

       

背景信息

**Background of LAMP1 Antibody**

Lysosome-associated membrane protein 1 (LAMP1) is a type I transmembrane glycoprotein predominantly localized in lysosomal membranes. It plays a critical role in maintaining lysosomal integrity, regulating autophagy, and mediating lysosome-phagosome fusion. Structurally, LAMP1 consists of two luminal domains heavily glycosylated to protect the lysosomal membrane from enzymatic degradation and a short cytoplasmic tail involved in intracellular trafficking.

LAMP1 antibodies are widely used as lysosomal markers in immunofluorescence, Western blotting, and flow cytometry to study lysosomal distribution, biogenesis, and dysfunction. These antibodies specifically target conserved epitopes in the luminal domain of LAMP1. enabling reliable detection across species like humans, mice, and rats.

Research applications include investigating lysosomal storage disorders, neurodegenerative diseases (e.g., Alzheimer’s), cancer (lysosomal exocytosis in metastasis), and immune responses (antigen presentation). Dysregulation of LAMP1 expression or trafficking is linked to pathological conditions, making it a biomarker for lysosomal activity and cellular stress.

Commercial LAMP1 antibodies vary in clonal specificity (e.g., H4A3. D2D11) and host species (mouse, rabbit), requiring validation for experimental contexts. Proper controls (e.g., knockout cells) are essential to confirm antibody specificity. Overall, LAMP1 antibodies are indispensable tools for exploring lysosome-related cellular mechanisms and disease pathogenesis.

       
LAMP1抗体;LAMP1;LAMP1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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