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CHGA 抗体

Rabbit Polyclonal CHGA Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-15

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
CHGA 抗体
英文名称：
Rabbit Polyclonal CHGA Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6639 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CHGA

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesCGA
WB Predicted band size51 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CHGA
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: P12417(CHGA  Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12417(CHGA  Antibody) at dilution 1/35. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12417(CHGA  Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是关于CHGA抗体的3篇参考文献概览(文献信息为虚拟示例，实际引用时请核实原文)：

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1. **文献名称**: "Chromogranin A as a Biomarker in Neuroendocrine Tumors: Validation of a Novel Immunohistochemical Antibody"

**作者**: Smith J, et al.

**摘要**: 研究验证了一种新型CHGA抗体的特异性，证明其在神经内分泌肿瘤(如胰腺神经内分泌瘤和嗜铬细胞瘤)组织中的高敏感性和诊断价值，支持其作为临床病理学标志物的应用。

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2. **文献名称**: "CHGA Antibodies in Cardiovascular Disease: Association with Hypertension and Cardiac Dysfunction"

**作者**: Lee S, et al.

**摘要**: 探讨了CHGA抗体水平与高血压和心功能不全的相关性，发现CHGA在交感神经活性调控中的作用，提示其可能作为心血管疾病风险的潜在生物标志物。

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3. **文献名称**: "Role of Chromogranin A Antibodies in Alzheimer’s Disease Pathology"

**作者**: Chen R, et al.

**摘要**: 通过CHGA抗体检测发现阿尔茨海默病患者脑脊液中CHGA水平升高，提示其可能参与神经炎症和淀粉样蛋白沉积机制，为神经退行性疾病研究提供新方向。

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如需具体文献，建议通过PubMed或Web of Science检索关键词(如“Chromogranin A antibody”或“CHGA biomarker”)，并结合实际研究领域筛选。

       

背景信息

Chromogranin A (CHGA) is a key acidic glycoprotein found in the secretory granules of neuroendocrine cells, including neurons, endocrine cells, and certain tumors. It plays a critical role in regulating hormone secretion, granulogenesis, and cell signaling by binding catecholamines and calcium. CHGA antibodies are essential tools for identifying neuroendocrine tissues and tumors, such as pheochromocytomas, neuroblastomas, and carcinoids, in diagnostic immunohistochemistry. These antibodies target specific epitopes of the CHGA protein, enabling visualization of its expression in pathological samples.

Beyond diagnostics, CHGA antibodies are used in research to study secretory mechanisms, neuroendocrine differentiation, and cardiovascular diseases, as CHGA-derived peptides (e.g., vasostatin, pancreastatin) influence vascular tone and glucose metabolism. Elevated circulating CHGA levels, detectable via antibody-based assays (e.g., ELISA), correlate with neuroendocrine tumor burden, heart failure, and hypertension. However, CHGA expression varies by tumor type and differentiation status, necessitating careful interpretation alongside clinical data.

Developed using recombinant CHGA or peptide fragments, these antibodies require validation for specificity across applications (Western blot, IHC, IF). Their utility underscores CHGA’s dual role as a structural component of secretory granules and a prohormone generating bioactive peptides, bridging neuroendocrine physiology and disease pathology.

       
CHGA 抗体;CHGA ;CHGA Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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