CHGA抗体;CHGA Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using CHGA mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human pancreatic tissues using CHGA mouse mAb with DAB staining.    

  
  

Chromogranin A (CHGA) is an acidic glycoprotein predominantly found in the secretory granules of neuroendocrine cells, including neurons, endocrine cells, and neuroendocrine tumors (NETs). It serves as a precursor protein for bioactive peptides like vasostatin, pancreastatin, and catestatin, which regulate hormone secretion, vascular tone, and inflammatory responses. CHGA plays a critical role in granulogenesis and stabilizing secretory granules by binding calcium and catecholamines.

CHGA antibodies are essential tools in diagnostics and research. In clinical pathology, they are widely used in immunohistochemistry (IHC) to identify neuroendocrine differentiation in tumors, aiding NET diagnosis and classification. Elevated serum CHGA levels, detected via ELISA or immunoblotting using CHGA antibodies, correlate with tumor burden and prognosis. In research, these antibodies help investigate CHGA's roles in cardiovascular diseases (e.g., hypertension, heart failure), neurological disorders (e.g., Alzheimer’s), and stress responses. Both polyclonal and monoclonal CHGA antibodies are available, often exhibiting cross-reactivity across species (human, mouse, rat), facilitating translational studies. Their specificity and reliability make them indispensable for understanding neuroendocrine system dynamics and disease mechanisms.