DACH1抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A172 and LO2 cell lysates, Primary antibody: P01266(DACH1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P01266(DACH1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

DACH1 antibody is a valuable tool in biomedical research, primarily used to detect the Dachshund homolog 1 (DACH1) protein, a key transcriptional regulator involved in developmental processes and disease pathogenesis. The DACH1 gene encodes a chromatin-associated protein that functions as a DNA-binding cofactor, interacting with transcription factors like AP-1 or Smad proteins to modulate gene expression. It plays critical roles in organogenesis, particularly in eye, limb, and pituitary gland development, by regulating cell fate determination and differentiation.

In cancer biology, DACH1 is recognized as a tumor suppressor. It inhibits cell proliferation, promotes apoptosis, and opposes epithelial-to-mesenchymal transition (EMT) by antagonizing oncogenic signaling pathways such as TGF-β and Ras/ERK. Reduced DACH1 expression correlates with poor prognosis in multiple cancers, including breast, prostate, and liver carcinomas. Research using DACH1 antibodies has revealed its nuclear localization and dynamic expression patterns during tissue development and tumor progression.

DACH1 antibodies are widely applied in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study protein expression, subcellular distribution, and interactions. Their specificity is validated through knockout controls or siRNA-based silencing. Emerging studies also explore DACH1's potential as a therapeutic target or biomarker. However, functional heterogeneity across tissues and cancer types underscores the need for context-specific interpretation of DACH1 antibody-based findings.