RAP1B抗体

The RAP1B antibody is a crucial tool in studying the Ras-related protein Rap1b, a member of the RAS superfamily of small GTPases. RAP1B plays a pivotal role in regulating diverse cellular processes, including cell adhesion, proliferation, differentiation, and intracellular signaling. It cycles between an inactive GDP-bound state and an active GTP-bound state, acting as a molecular switch to control pathways like integrin-mediated signaling, MAP kinase cascades, and cAMP signaling. Dysregulation of RAP1B has been implicated in various pathologies, such as cancer, cardiovascular diseases, and immune disorders. The RAP1B antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, subcellular localization, and activation states in tissues or cell lines. It helps researchers investigate RAP1B's functional interactions, post-translational modifications, and its role in disease mechanisms. Commercial RAP1B antibodies are typically raised against specific epitopes, often corresponding to conserved regions of the human protein, and validated for cross-reactivity in model organisms like mice and rats. Recent studies highlight its potential as a therapeutic target, particularly in cancers where RAP1B modulates tumor growth, metastasis, or drug resistance.