SERPINA3抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using SERPINA3 mouse mAb against A549 cell lysate.    

  
  

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     Flow cytometric analysis of A549 cells using SERPINA3 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using SERPINA3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using SERPINA3 mouse mAb with DAB staining.    

  
  

SERPINA3. also known as alpha-1-antichymotrypsin (AACT), is a member of the serine protease inhibitor (serpin) superfamily. It primarily inhibits proteases like cathepsin G and chymotrypsin, playing a regulatory role in inflammation, immune response, and tissue remodeling. Encoded by the *SERPINA3* gene, this glycoprotein is synthesized in the liver and secreted into the bloodstream as an acute-phase reactant, with levels rising during infection, trauma, or chronic inflammation. SERPINA3 is also expressed in extrahepatic tissues, including the brain, lungs, and prostate.

SERPINA3 antibodies are essential tools for studying its biological functions and disease associations. Dysregulation of SERPINA3 has been linked to conditions such as Alzheimer’s disease (where it co-localizes with amyloid-beta plaques), liver fibrosis, chronic obstructive pulmonary disease (COPD), and certain cancers. Antibodies targeting SERPINA3 enable detection and quantification in biological samples via techniques like Western blot, immunohistochemistry (IHC), and ELISA. They help explore its dual role as both a protease inhibitor and a pathogenic mediator in inflammatory processes.

Commercial SERPINA3 antibodies are typically raised against specific epitopes, often recognizing both precursor and mature forms. Researchers use these antibodies to investigate tissue-specific expression patterns, protein-protein interactions, and mechanisms underlying SERPINA3’s involvement in disease progression. Recent studies also highlight its potential as a biomarker for inflammatory or neurodegenerative disorders, driving demand for high-specificity antibodies in diagnostic and therapeutic research.