AACT α-1抗胰糜蛋白酶/SERPINA3抗体

Rabbit  Anti-AACT Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:AACT

IR:Immunogen Range:121-320/423

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:12

Swiss Prot:P01011

Source:KLH conjugated synthetic peptide derived from human AACT-Alpha1:121-320/423 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Alpha 1-Antichymotrypsin, a member of the serine proteinase inhibitor (serpin) family, inhibits neutrophil proteinase cathepsin G and mast cell chymases, and protects the lower respiratory tract from damage by proteolytic enzymes. It contains a reactive centre loop, which interacts with cognate proteinases, resulting in loop cleavage and a major conformational change. Recently, alpha 1-antichymotrypsin has been identified as a major constituent of the neurofibrillary plaques associated with Alzheimers disease, and in vitro studies have shown that it enhances the rate of amyloid-fibril formation. These observations and recent genetic evidence suggest that alpha 1-antichymotrypsin is important in the pathogenesis of Alzheimers disease

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat

本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！