阿瑞匹坦;阿瑞吡坦； 170729-80-3；Aprepitant 新品

产品描述

等级：活性药物成分（API）

化学名称：5-{[(2R,3S)-2-{(1R)-1-[3,5-二（三氟甲基）苯基]乙氧基}-3-（4-氟苯基）morpholin-4-基]甲基}-1,2-二氢- 3h -1,2,4-三唑-3-o

分子式：C23H21F7N4O3

分子量：534.427

规格:EP

外观:粉

总杂质：不大于0.5%

纯度：不低于99%

残留溶剂：完全符合ICH Q3C要求

致突变杂质：完全符合ICH M8

亚硝胺评估：可用

粒度：可根据客户要求进行普通级或研磨/筛分

储存方法：室温

生产能力：商用

标准包装：1kg/袋，5kg/袋，或根据客户要求

产品用途

阿瑞吡坦是一种止吐化合物，属于“P物质”拮抗剂（SPA），其作用是阻断神经激肽1（Nk1）受体。用于预防化疗引起的急性和延迟性恶心呕吐（CINV）和预防术后恶心呕吐。它也可用于治疗周期性呕吐综合征和癌症治疗期间发生的晚期化疗引起的呕吐。阿瑞吡坦通过阻断Nk1受体释放的信号减轻患者呕吐的情况。Nk1是g蛋白偶联受体，其配体为P物质（SP）。呕吐反射需要高浓度的SP。阿瑞吡坦阻断SP-NK1信号激活呕吐反射的过程。 

联系方式

四川青木制药有限公司

四川省眉山市东坡区经济开发区东区顺江大道南段55号

国际营销部(International):

Email: sales@eastonpharma.cn 

Tel: 028-87827187

国内营销部(Mainland)：

李经理 13880480517   

杨经理 15982276454

Product Description

• Grade: Active Pharmaceutical Ingredient(API)

• Chemical Name: 5-{[(2R,3S)-2-{(1R)-1-[3,5-Bis(trifluormethyl)phenyl]ethoxy}-3-(4-fluorphenyl)morpholin-4-yl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-on

• Molecular Formula: C23H21F7N4O3

• Molecular Weight: 534.427

• Specification: EP

• Appearance: Powder

• Total impurities: not more than 0.5%

• Purity: not less than 99%

• Residual Solvents: fully comply with ICH Q3C

• Mutagenic impurities: fully comply with ICH M8

• Nitrosamine assessment: available

• Particle size: regular grade or milling/sieving according to      customer’s requirement.

• Storage: Room temperature

• Production capacity: Commercial

• Standard Package: 1kg/bag, 5kg/bag, or according to the      customer’s requirement

Applications 

• Aprepitant is an antiemetic chemical compound that  belongs to “substance P” antagonists (SPA) with its effect being blocking      the neurokinin 1(Nk1) receptor. It is used for the prevention of acute and delayed chemotherapy-induced nausea and        vomiting(CINV) and  for the prevention of postoperative nausea and vomiting. It can also beused for the treatment of cyclic vomiting syndrome and late-stage  chemotherapy-induced vomiting occurring during cancer treatment.

• Aprepitant alleviates the case of vomiting in patients through balking the signals released by Nk1 receptors. Nk1 is aG-protein-coupled receptor with its ligand being substance P (SP). The high concentration of SP is required for the vomiting reflex. Aprepitant blocks the process of SP-NK1 signaling in activating the vomiting reflex.

Contact Information

Sichuan Qingmu Pharmaceutical Co., Ltd.

Add: No. 55, South Shunjiang Avenue, East Economic Development Zone, Dongpo District, Meishan City, Sichuan, 620036, China

International Marketing Department: 

Email: sales@eastonpharma.cn 

Tel: 0086-28-87827187