Fz7-21/2247635-23-8/多肽Ac-LPSDDLEFWCHVMY-NH2

Product Name：  Fz7-21

CAS No.：2247635-23-8

Synonyms：多肽Ac-LPSDDLEFWCHVMY-NH2

Catalog No.：PYC-162

Description：Fz7-21是一种有效的 FZD7受体的肽拮抗剂，其是由14个氨基酸组成的多肽，可以选择性地结合到 FZD7 CRD 亚类，并改变 CRD 的构象及其脂质结合槽的结构。人和小鼠 FZD7 CRD 的EC50 值分别为 58 和 34 nM。Fz7-21 损害 FZD7 在 Wnt-β-catenin 信号传导中的功能和肠类器官中的干细胞功能。

Fz7-21 is an effective peptide antagonist of FZD7 receptor, which is a peptide composed of 14 amino acids that can selectively bind to the FZD7 CRD subclass and alter the conformation of CRD and the structure of its lipid binding slot. The EC50 values of FZD7 CRD in humans and mice were 58 and 34 nM, respectively. Fz7-21 impairs the function of FZD7 in Wnt - β - catenin signaling and the stem cell function in intestinal organoids.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	Ac-LPSDDLEFWCHVMY-NH2
Sequence(3-letter code)	Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2
Peptide Structure
Molecular Formula	C83H114N18O23S2
Molecular Weight	1796.05

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