卡利奇霉素新品

Calicheamicin
108212-75-5

询价 10g 起订

50g 起订

100g 起订

江西更新日期：2024-11-07

江西瑞威尔生物科技有限公司

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产品详情:

中文名称：: 卡利奇霉素

英文名称：: Calicheamicin

CAS号：: 108212-75-5

品牌：: 江西瑞威尔

产地：: 国产

保存条件：: 2-8°C低温储存

纯度规格：: 98%

产品类别：: 原料药

是否进口：: 否

用途：: 科研，试剂，出口

含量：: 98%

中文名	CALICHEAMICIN GAMMA(1)I
英文名	calicheamicin gamma(1)I
别名	卡奇霉素刺孢霉素卡里奇霉素卡利奇霉素卡奇霉素Γ1 加利西霉素Γ1 卡奇霉素 GAMMA1 CALICHEAMICIN卡利奇霉素
英文别名	Calicheamicin γ1 Calichemicin gamma1 LL-E 33288 gamma1-I calicheamicin gamma calicheamicin gamma(1)I CALICHEAMICIN GAMMA(1)I Carbamic acid, ((1R,4Z,8S,13E)-8-((4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-o-methyl-alpha-L-mannopyranopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methylbenzoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-2-o-(2,4-dideoxy-4-(ethylamino)-3-o-methyl-alpha-L-threo-pentopyranosyl)-beta-D-glucopyranosyl)oxy)-1-hydroxy-13-(2-(methyltrithio)ethylidene)-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)-, methyl ester Benzenecarbothioic acid, 4-((6-deoxy-3-o-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methyl-, 4''-ester with methyl (8-((4,6-dideoxy-2-o-(2,4-dideoxy-4-(ethylamino)-3-o-methyl-alpha-L-threo-pentapyranosyl)-4-(((2,6-dideoxy-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-beta-D-glucopyranosyl)oxy)-1-hydroxy-13-(2-(methyltrithio)ethylidene)-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)carbamate, (1R-(1R,4Z,8S,13E))-
CAS	108212-75-5
化学式	C55H74IN3O21S4
分子量	1368.34
密度	1.57±0.1 g/cm3(Predicted)
比旋光度	D26 -124° (c = 0.98%, EtOH)
酸度系数	7.13±0.60(Predicted)
存储条件	2-8℃
体外研究	PF-06647263 (anti-EFNA4-ADC) is generated via conjugation of hE22 lysine residues to the AcButDMH-N-Ac-calicheamicin-γ1 linker-payload with an average drug-to-antibody ratio (DAR) of 4.6. PF-06647263 elicits antigen- and concentration-dependent cytotoxicity, as exposure to PF-06647263 for 96 hours results in cell death (EC 50 = appr 1 ng/mL). CMC-544, consisting of a humanized CD22 Ab linked to calicheamicin, is effective in pediatric primary B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells in vitro. CMC-544 induces cell death in various ALL cell lines in a dose- and time-dependent way, with IC 50 values ranging from 0.15 to 4.9 ng/mL. CMC-544 (10 ng/mL) is effective and specific in primary BCP-ALL cells. In CMC-544-treated cells, the level of CD22 has decreased relative to that on G5/44-treated cells and continued to decrease.
体内研究	An ADC comprising a humanized anti-EFNA4 monoclonal antibody conjugated to the DNA-damaging agent calicheamicin achieves sustained tumor regressions in both TNBC and ovarian cancer PDX in vivo. PF-06647263 (0.27, 0.36 mg/kg) results in significant tumor regressions in TNBC xenografts.
下游产品	N-乙酰-凯立霉素

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