卡利奇霉素

Calicheamicin
108212-75-5

询价 10g 起订

50g 起订

100g 起订

江西更新日期：2024-11-29

江西瑞威尔生物科技有限公司

VIP3年

联系人：龙珑

电话：185-0276-2003拨打

邮箱：435918333@qq.com

产品详情:

中文名称：: 卡利奇霉素

英文名称：: Calicheamicin

CAS号：: 108212-75-5

品牌：: 江西瑞威尔

产地：: 国产

保存条件：: 2-8°C低温储存

纯度规格：: 98%

产品类别：: 原料药

是否进口：: 否

用途：: 科研，试剂，出口

含量：: 98%

中文名	CALICHEAMICIN GAMMA(1)I
英文名	calicheamicin gamma(1)I
别名	卡奇霉素刺孢霉素卡里奇霉素卡利奇霉素卡奇霉素Γ1 加利西霉素Γ1 卡奇霉素 GAMMA1 CALICHEAMICIN卡利奇霉素
英文别名	Calicheamicin γ1 Calichemicin gamma1 LL-E 33288 gamma1-I calicheamicin gamma calicheamicin gamma(1)I CALICHEAMICIN GAMMA(1)I Carbamic acid, ((1R,4Z,8S,13E)-8-((4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-o-methyl-alpha-L-mannopyranopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methylbenzoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-2-o-(2,4-dideoxy-4-(ethylamino)-3-o-methyl-alpha-L-threo-pentopyranosyl)-beta-D-glucopyranosyl)oxy)-1-hydroxy-13-(2-(methyltrithio)ethylidene)-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)-, methyl ester Benzenecarbothioic acid, 4-((6-deoxy-3-o-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methyl-, 4''-ester with methyl (8-((4,6-dideoxy-2-o-(2,4-dideoxy-4-(ethylamino)-3-o-methyl-alpha-L-threo-pentapyranosyl)-4-(((2,6-dideoxy-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-beta-D-glucopyranosyl)oxy)-1-hydroxy-13-(2-(methyltrithio)ethylidene)-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)carbamate, (1R-(1R,4Z,8S,13E))-
CAS	108212-75-5
化学式	C55H74IN3O21S4
分子量	1368.34
密度	1.57±0.1 g/cm3(Predicted)
比旋光度	D26 -124° (c = 0.98%, EtOH)
酸度系数	7.13±0.60(Predicted)
存储条件	2-8℃
体外研究	PF-06647263 (anti-EFNA4-ADC) is generated via conjugation of hE22 lysine residues to the AcButDMH-N-Ac-calicheamicin-γ1 linker-payload with an average drug-to-antibody ratio (DAR) of 4.6. PF-06647263 elicits antigen- and concentration-dependent cytotoxicity, as exposure to PF-06647263 for 96 hours results in cell death (EC 50 = appr 1 ng/mL). CMC-544, consisting of a humanized CD22 Ab linked to calicheamicin, is effective in pediatric primary B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells in vitro. CMC-544 induces cell death in various ALL cell lines in a dose- and time-dependent way, with IC 50 values ranging from 0.15 to 4.9 ng/mL. CMC-544 (10 ng/mL) is effective and specific in primary BCP-ALL cells. In CMC-544-treated cells, the level of CD22 has decreased relative to that on G5/44-treated cells and continued to decrease.
体内研究	An ADC comprising a humanized anti-EFNA4 monoclonal antibody conjugated to the DNA-damaging agent calicheamicin achieves sustained tumor regressions in both TNBC and ovarian cancer PDX in vivo. PF-06647263 (0.27, 0.36 mg/kg) results in significant tumor regressions in TNBC xenografts.
下游产品	N-乙酰-凯立霉素

卡利奇霉素原料;卡利奇霉素现货价格;卡利奇霉素生产工厂;卡利奇霉素环评公示;卡利奇霉素工艺流程;

江西瑞威尔生物科技有限公司，注册地江西省峡江县，在南昌设有办事处，武汉设有分公司。公司依托母公司江右云商丰富的互联网运营优势及数字中台技术支持，将科技贯穿于研发、生产、检测及采购、仓储、销售的所有环节，满足了科研客户分散、品种要求多样化、频繁购买且单次量小的需求，在业内形成了良好的口碑。公司深耕科研试剂领域，科研试剂产品广泛应用于高等院校、科研院所以及生物医药、新材料、新能源、节能环保、航空航天等高新技术产业和战略性新兴产业相关企业的研发机构，产品使用者多为科学家和一线研发工程师，赢得了众多知名客户的信赖。目前与公司发生直接业务往来的科研机构、大学院校、政府、军队等企业和机构超过数量200家。