3,4-二羟基苄胺·氢溴酸|T10104|TargetMol

3,4-Dihydroxybenzylamine hydrobromide
16290-26-9

￥128 25mg 起订

￥177 50mg 起订

￥250 100mg 起订

上海更新日期：2024-09-30

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产品详情:

中文名称：: 3,4-二羟基苄胺·氢溴酸

英文名称：: 3,4-Dihydroxybenzylamine hydrobromide

CAS号：: 16290-26-9

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 97.28%

产品类别：: 抑制剂

货号：: T10104

Product Introduction

Bioactivity

名称	3,4-Dihydroxybenzylamine hydrobromide
描述	3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.
细胞实验	Cell Line: Human and Murine Melanoma Cell Lines; Non-Melanoma Cell Lines Concentration: 1 μM-10 mM Incubation Time: 48 hours [1]
动物实验	Animal Model: C57BL/6 mice with B6D2F1 cells Dosage: 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg Administration: Intraperitoneal injection [2]
体外活性	3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) inhibits the growth of all melanoma cell lines (IC50 = 100 μM) and the SK-MELB cell line (IC50 = 122 μM). The IC50 values are 30, 84,90, and 68 μM for Human SK-MEL-30, SK-MEL-2, SK-MEL-3,RPMI-7951 cells, respectively. 3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) cytotoxicity in SK-MEL-2 and SK-MEL-28 cell lines can be enhanced by application of buthionine sulfoximine (BSO). BSO treatment sensitizes marginally pigmented cells to the effects of 3,4-DHBA, and the presence of decreses IC50 values of 3,4-DHBA by 127% in the SK-MEL-28 cell line and by 148% in the SK-MEL-2 cell line. 3,4-Dihydroxybenzylamine hydrobromide exhibits IC50values of 10, 25, 67, and 184 μM for S91A, S91B, L1210, and SCC-25 cells, respectively[1].
体内活性	3,4-Dihydroxybenzylamine hydrobromide (200, 400, 600 and 800 mg/kg; i.p.; 21 days) has different effects at different doses, the median life-span are 17, 24.5, 26, 29 and 25 days respectively. 3,4-Dihydroxybenzylamine hydrobromide (1000 mg/kg; i.p.; 7 days) has the least toxic effect in non-tumor-bearing B6D2F1 mice,and mice is tolerated at this dose[2].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 80 mg/mL (363.54 mM), Sonication is recommended.
关键字	NSC-263475 Hydrobromide \| Inhibitor \| DNA polymerase \| Tumor \| NSC263475 \| melanoma \| NSC-263475 \| DNA/RNA Synthesis \| 3,4-Dihydroxybenzylamine \| inhibit \| 3,4Dihydroxybenzylamine hydrobromide \| tyrosinase \| NSC263475 Hydrobromide \| NSC 263475 Hydrobromide \| NSC 263475 \| 3,4-Dihydroxybenzylamine Hydrobromide \| 3,4 Dihydroxybenzylamine hydrobromide
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相关库	抑制剂库 \| 经典已知活性库 \| 抗癌化合物库 \| 已知活性化合物库 \| 抗衰老化合物库 \| DNA 损伤和修复分子库

NSC 263475 hydrobromide|||3,4-二羟基苄胺·氢溴酸|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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