3,4-二羟基苄胺·氢溴酸|T10104|TargetMol

3,4-Dihydroxybenzylamine hydrobromide
16290-26-9

￥128 25mg 起订

￥177 50mg 起订

￥250 100mg 起订

上海更新日期：2024-09-30

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产品详情:

中文名称：: 3,4-二羟基苄胺·氢溴酸

英文名称：: 3,4-Dihydroxybenzylamine hydrobromide

CAS号：: 16290-26-9

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 97.28%

产品类别：: 抑制剂

货号：: T10104

Product Introduction

Bioactivity

Name	3,4-Dihydroxybenzylamine hydrobromide
Description	3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.
Cell Research	Cell Line: Human and Murine Melanoma Cell Lines; Non-Melanoma Cell Lines Concentration: 1 μM-10 mM Incubation Time: 48 hours [1]
Animal Research	Animal Model: C57BL/6 mice with B6D2F1 cells Dosage: 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg Administration: Intraperitoneal injection [2]
In vitro	3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) inhibits the growth of all melanoma cell lines (IC50 = 100 μM) and the SK-MELB cell line (IC50 = 122 μM). The IC50 values are 30, 84,90, and 68 μM for Human SK-MEL-30, SK-MEL-2, SK-MEL-3,RPMI-7951 cells, respectively. 3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) cytotoxicity in SK-MEL-2 and SK-MEL-28 cell lines can be enhanced by application of buthionine sulfoximine (BSO). BSO treatment sensitizes marginally pigmented cells to the effects of 3,4-DHBA, and the presence of decreses IC50 values of 3,4-DHBA by 127% in the SK-MEL-28 cell line and by 148% in the SK-MEL-2 cell line. 3,4-Dihydroxybenzylamine hydrobromide exhibits IC50values of 10, 25, 67, and 184 μM for S91A, S91B, L1210, and SCC-25 cells, respectively[1].
In vivo	3,4-Dihydroxybenzylamine hydrobromide (200, 400, 600 and 800 mg/kg; i.p.; 21 days) has different effects at different doses, the median life-span are 17, 24.5, 26, 29 and 25 days respectively. 3,4-Dihydroxybenzylamine hydrobromide (1000 mg/kg; i.p.; 7 days) has the least toxic effect in non-tumor-bearing B6D2F1 mice,and mice is tolerated at this dose[2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 80 mg/mL (363.54 mM), Sonication is recommended.
Keywords	NSC-263475 Hydrobromide \| Inhibitor \| DNA polymerase \| Tumor \| NSC263475 \| melanoma \| NSC-263475 \| DNA/RNA Synthesis \| 3,4-Dihydroxybenzylamine \| inhibit \| 3,4Dihydroxybenzylamine hydrobromide \| tyrosinase \| NSC263475 Hydrobromide \| NSC 263475 Hydrobromide \| NSC 263475 \| 3,4-Dihydroxybenzylamine Hydrobromide \| 3,4 Dihydroxybenzylamine hydrobromide
Inhibitors Related	Acyclovir \| 2,4-D \| Guanidine hydrochloride \| Folic acid \| Resveratrol \| 5-Fluorouracil \| Temozolomide \| Thymidine \| Ribavirin \| Rifampicin
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Anti-Cancer Compound Library \| Bioactive Compounds Library Max \| Anti-Aging Compound Library \| DNA Damage & Repair Compound Library

NSC 263475 hydrobromide|||3,4-二羟基苄胺·氢溴酸|TargetMol

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