| 名称 | Pipequaline hydrochloride |
| 描述 | Pipequaline hydrochloride (PK-8165 hydrochloride) is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic. |
| 动物实验 | Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3]. |
| 体外活性 | Pipequaline is extensively bound to plasma proteins: i.e. human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lipoproteins and blood cells, mainly erythrocytes[1]. |
| 体内活性 | Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : >30 mg/mL (94.8 mM), Sonication is recommended.
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| 关键字 | γ-Aminobutyric acid Receptor | PK-8165 Hydrochloride | PK8165 Hydrochloride | PK-8165 | PK8165 | PK 8165 Hydrochloride | PK 8165 | Pipequaline hydrochloride | Pipequaline | Inhibitor | inhibit | Gamma-aminobutyric acid Receptor | GABAReceptor | GABAA | GABA Receptor |
| 相关产品 | Penicillin G sodium salt | p-Hydroxybenzaldehyde | Valproic acid sodium salt | Valproic Acid | Methionine | Urethane | Methyl eugenol | Dihydromyricetin | (-)-α-Pinene | Imidazoleacetic acid hydrochloride | Baicalin | Nipecotic acid |
| 相关库 | 神经保护化合物库 | 抗帕金森病化合物库 | 经典已知活性库 | 抗癌化合物库 | 已知活性化合物库 | 神经信号分子库 | 离子通道库 | 抗抑郁症化合物库 | 膜蛋白靶向化合物库 | 神经退行性疾病化合物库 | 疼痛相关化合物库 | 表型筛选靶点鉴定库 |
