HDAC6 抑制剂|T6327|TargetMol

Tubacin
537049-40-4

￥652 1mg 起订

￥1990 5mg 起订

￥3890 10mg 起订

上海更新日期：2024-12-12

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: HDAC6 抑制剂

英文名称：: Tubacin

CAS号：: 537049-40-4

品牌：: TargetMol

产地：: 美国

保存条件：: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 98.71%

产品类别：: 抑制剂

货号：: T6327

Product Introduction

Bioactivity

Name	Tubacin
Description	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
Cell Research	Cell lines: Drug-sensitive (MM.1S,U266,INA-6,and RPMI8226) and drug-resistant (RPMI-LR5 and RPMI-Dox40) MM cell lines. Concentrations: ~20 μM. Incubation Time: 72 hours. Method:The inhibitory effect of bortezomib and/or tubacin on MM cell growth is assessed by measuring 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) dye absorbance.All experiments are performed in quadruplicate.
Kinase Assay	Enzyme Inhibition Assay:Enzyme inhibition assays are performed using the Reaction Biology HDAC Spectrum platform. The HDAC1, 2, 4, 5, 6, 7, 8, 9, 10, and 11 assays used isolated recombinant human protein; HDAC3/NcoR2 complex is used for the HDAC3 assay. Substrate for HDAC1, 2, 3, 6, 10, and 11 assays is a fluorogenic peptide from p53 residues 379-382 (RHKKAc); substrate for HDAC8 is fluorogenic diacyl peptide based on residues 379-382 of p53 (RHKAcKAc). Acetyl-Lys(trifluoroacetyl)-AMC substrate is used for HDAC4, 5, 7, and 9 assays. Compounds are dissolved in DMSO and tested in 10-dose IC50 mode with 3-fold serial dilution starting at 30 μM. Control Compound Trichostatin A (TSA) is tested in a 10-dose IC50 with 3-fold serial dilution starting at 5 μM. IC50 values are extracted by curve-fitting the dose/response slopes.
Animal Research	Animal Models: Athymic nude mice implanted with angioreactorsFormulation: DMSODosages: --Administration: Tubacin is filled in semiclosed angioreactors, and then implanted into the mice.
In vitro	Tubacin不直接稳定微管，通过提高A549细胞中α-微管蛋白乙酰化水平（EC50为2.5μM）发挥作用。Tubacin抑制HDAC6介导的α-微管蛋白去乙酰化作用，并能阻止野生型及HDAC6过表达细胞的迁移。与紫杉醇联合使用时，Tubacin可协同增强微管蛋白乙酰化。同时，Tubacin显著抑制药物敏感和药物抗性多发性骨髓瘤(MM)细胞增长（IC50为5–20μM），并通过激活caspases诱导细胞凋亡。
In vivo	在鸡胚中，Tubacin抑制HDAC6的活性可以减少在matrigel/尼龙网中新血管的形成。在小鼠体内植入的血管生成器中，Tubacin同样阻碍了新血管的形成。
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 93 mg/mL (128.8 mM) Ethanol : <1 mg/mL H2O : <1 mg/mL
Keywords	Inhibitor \| HDAC \| Virus Protease \| inhibit \| Tubacin \| Histone deacetylases
Inhibitors Related	Valproic acid sodium salt \| 4-Phenylbutyric acid \| Anthraquinone \| Panobinostat \| Theophylline \| Curcumin \| 2-Phenylethanol \| Sodium 4-phenylbutyrate \| Phenytoin sodium
Related Compound Libraries	Bioactive Compound Library \| Bioactive Compounds Library Max \| Anti-Aging Compound Library

Tubacin|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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