化合物 6-Thio-dG|T6746|TargetMol

6-Thio-2'-Deoxyguanosine
789-61-7

￥193 1mg 起订

￥493 5mg 起订

￥690 10mg 起订

上海更新日期：2024-09-30

TargetMol中国（陶术生物）

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联系人：邵小姐

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邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 6-Thio-dG

英文名称：: 6-Thio-2'-Deoxyguanosine

CAS号：: 789-61-7

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 97.52%

产品类别：: 抑制剂

货号：: T6746

Product Introduction

Bioactivity

Name	6-Thio-2'-Deoxyguanosine
Description	6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.
Cell Research	Cells are plated in growth media in 96-well plates. Cells are incubated for 1 week and treated with varying concentrations of 6-thio-dG and 6-thioguanine or DMSO every 3 days. The 96-well plates are analyzed according the manufacturer's directions for the CellTiterGlo luminescent cell viability assay to obtain IC50 values. The IC50 is defined as the concentration of drug at which 50% of the cells are inhibited by the drug. Sigmoidal dose–response curves are used to calculate IC50 values. All samples are analyzed in triplicate, and SDs are from two independent experiments.(Only for Reference)
In vitro	6-Thio-dG在表达端粒酶(telomerase)的人类癌细胞和表达hTERT的人类成纤维细胞中引起端粒功能障碍，并导致端粒逐渐缩短。在实验中测试的癌细胞中，6-thio-dG抑制细胞活性，其IC50值介于0.7至2.9 μM之间。[1]
In vivo	在携带A549肺癌异种移植瘤的小鼠中，6-Thio-dG（2 mg/kg，腹腔注射）通过诱导端粒功能失常，降低了A549细胞的肿瘤形成能力。[1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 52 mg/mL (183.5 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble)
Keywords	Inhibitor \| beta-TGdR \| inhibit \| DNA/RNA Synthesis \| b-TGdR \| 6Thio2'Deoxyguanosine \| 6-Thio-2'-Deoxyguanosine \| 6 Thio 2' Deoxyguanosine
Inhibitors Related	Acyclovir \| 2,4-D \| Guanidine hydrochloride \| Trimethoprim \| Folic acid \| Resveratrol \| 5-Fluorouracil \| Temozolomide \| Thymidine \| Ribavirin \| Azelaic acid \| Rifampicin
Related Compound Libraries	Nucleotide Compound Library \| Bioactive Compound Library \| Anti-Cancer Active Compound Library \| Anti-Cancer Compound Library \| Bioactive Compounds Library Max \| Anti-Colorectal Cancer Compound Library \| Anti-Aging Compound Library \| Preclinical Compound Library \| NO PAINS Compound Library \| DNA Damage & Repair Compound Library

β-TGdR|||6-Thio-dG|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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