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网站主页 SSD114 HYDROCHLORIDE 化合物 SSD114 hydrochloride
  • 化合物 SSD114 hydrochloride|T4522|TargetMol

化合物 SSD114 hydrochloride|T4522|TargetMol

SSD114 HCl
2319790-02-6
￥298 1mg 起订
￥738 5mg 起订
￥1190 10mg 起订
上海 更新日期：2026-09-26

TargetMol中国（陶术生物）

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高新技术企业

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联系人：邵小姐
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邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 SSD114 hydrochloride
英文名称：
SSD114 HCl
CAS号：
2319790-02-6
品牌：
TargetMol
产地：
美国
保存条件：
Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
纯度规格：
99.03%
产品类别：
抑制剂
货号：
T001|T4522

Product Introduction

Bioactivity

名称SSD114 HCl
描述SSD114 is a novel GABAB receptor positive allosteric modulator.
细胞实验Cells are transfected and seeded into 96-well microplates. 24 h after transfection, cells are washed twice with PBS and incubated in the presence or absence of SSD114 hydrochloride (different concentrations) for 15 min before substrate addition in a 96-well microplate. The Bioluminescence resonance energy transfer (BRET) ratio is calculated as the emission of YFP (530 to 570 nm) over the emission of RLuc (370 to 470 nm). The curves are fitted using Graph Pad Prism 5.0. The amplitude-weighted mean time constant is obtained by fitting the BRET recovery phase to a double exponential function [1].
动物实验Male Sprague-Dawley rats and DBA mice, weighing 200 to 250 and 20 to 25 g, respectively, are used. On the test day, mice are divided into six groups (n=6 each) matched by body weight. Mice are treated acutely and intraperitoneally with 0, 1, 3, 10, 30, and 100 mg/kg SSD114 hydrochloride and sedation/hypnosis are measured. Specifically, after baclofen injection, each mouse is placed on its back once every 60 s until it is unable to right itself within 60 s. The time between baclofen injection and the start of the 60-s interval during which the mouse is unable to right itself is measured at the onset of loss of righting reflex (LORR). Each mouse is then left undisturbed on its back until it spontaneously regained its righting reflex (determined as having at least three paws under its body). Complete recovery of the righting reflex is defined as the mouse being able to turn itself upright twice more within 60 s. If this criterion is not fulfilled, the mouse is left undisturbed until it spontaneously regained its righting reflex. The time between loss and recovery of the righting reflex is monitored in each mouse and defined as the duration of LORR. Observations are conducted by an operator unaware of the drug treatment [1].
体外活性在含有10μM GABA的条件下，25μM的SSD114 hydrochloride 显著增加GABA单独诱导的[35S]GTPγS激活水平，大约增至基础水平的170%。SSD114 hydrochloride （15或30μM）引起GABA浓度-反应曲线向左移动，并在最高浓度下轻微增加GABA的最大刺激效果。在15和30μM SSD114 hydrochloride 的共同存在下，GABA的EC50分别降低了2倍和2.5倍，而最大刺激效果（Emax）仅在30μM浓度下被增强，达到基础值的161±5.09%[1]。
体内活性SSD114 hydrochloride预处理显著缩短了失去翻正反射（LORR）的起始时间[F(5,30)=4.55, P<0.005]。后续分析表明，与对照组相比，接受等于或高于10 mg/kg SSD114 hydrochloride剂量预处理的小鼠组LORR起始时间显著缩短。此外，SSD114 hydrochloride预处理延长了LORR的持续时间[F(5,30)=4.81, P<0.005]。后续分析指出，与对照组相比，接受10和100 mg/kg SSD114 hydrochloride预处理的小鼠组LORR持续时间显著延长[1]。
存储条件Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度DMSO : 45 mg/mL (116.03 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (6.45 mM), Sonication is recommended.
关键字SSD-114 hydrochloride | SSD114 Hydrochloride | SSD 114 Hydrochloride | GABAReceptor | GABAB | GABA Receptor
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SSD114 HCl;TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (14年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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