佐他莫司|T6033|TargetMol
Zotarolimus
221877-54-9
221877-54-9
¥553
1mg
起订
¥793
2mg
起订
¥1230
5mg
起订
上海 更新日期:2024-12-12
产品详情:
- 中文名称:
- 佐他莫司
- 英文名称:
- Zotarolimus
- CAS号:
- 221877-54-9
- 品牌:
- TargetMol
- 产地:
- 美国
- 保存条件:
- Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
- 纯度规格:
- ≥98%
- 产品类别:
- 抑制剂
- 货号:
- T6033
Product Introduction
Bioactivity
名称 | Zotarolimus |
描述 | Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM). |
细胞实验 | Cell proliferation is assayed by measuring tritiated thymidine incorporation in vitro. Human coronary artery cells (hCa) are seeded into tissue culture flasks for expansion and applied to 96-well plates at desired density in complete media (5000 hCaSMC; 10 000 hCaEC). After 2 days, complete media is replaced with incomplete media to synchronize cells and induce G0 state. Two days later, incomplete media are removed and replaced with complete media (serum/growth factors) to induce G0 to G1 transition. Complete media also contain drug at desired concentrations to determine its effects on cell proliferation. On day 7, 3H-thymidine is added to cells to monitor DNA synthesis, and cells are harvested after overnight incorporation of radioactivity. After an incubation period of 72 h, 25 μL (1 μCi/well) of 3H-thymidine are added to each well. The cells are incubated at 37°C for 16-18 h to allow for incorporation of 3H-thymidine into newly synthesized DNA and the cells harvested onto 96-well plates containing bonded glass fibre filters . The filter plates are air-dried overnight, MicroScint-20 (25 μL) added to each filter well and counted. Drug activity is determined by the inhibition of 3H-thymidine incorporation into newly synthesized DNA relative to cells grown in complete media. (Only for Reference) |
激酶实验 | zotarolimus (10 pM-1 μM) in buffer A (2% BSA and 0.2% Tween-20 in D-PBS) is used in the assay of Binding Affinity to FKBP12. |
动物实验 | Male Sprague-Dawley rats was administrate by intravenous or oral Zotarolimus(2.5 mg/kg)dissolved inethanol: propylene glycol: cremophor EL: D5W vehicle (20: 30: 2: 48, by volume). |
体外活性 | 在平滑肌细胞(IC50=2.9 nM)和内皮细胞(IC50=2.6 nM)中,Zotarolimus有效抑制细胞增殖。 |
体内活性 | Zotarolimus 强效抑制剂,对辅助性迟发型超敏反应(DTH)(ED50=1.72 mg/kg/day)、实验性自身免疫性脑炎(EAE)(ED50=1.17 mg/kg/day)、以及心脏移植排斥反应(ED50=3.71 mg/kg/day)表现出显著的抑制作用。 |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | Ethanol : 93 mg/mL (96.3 mM) DMSO : 93 mg/mL (96.3 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
关键字 | coronary | ABT 578 | drug-eluting | inhibit | artery | disease | restenosis | Rapamycin | Zotarolimus | ABT578 | immunosuppressant | A-179578 | stents | A179578 | Inhibitor |
相关产品 | α-Hydroxyglutaric Acid Lithium | P-2281 | Capivasertib | Rapamycin | Bimiralisib | L-Leucine | GDC0084 | Tacrolimus | Dihydromyricetin | PI3K/Akt/mTOR-IN-2 | Sapanisertib | (+)-Usnic acid |
相关库 | 经典已知活性库 | 已知活性化合物库 | 激酶抑制剂库 | 抗衰老化合物库 | 药物功能重定位化合物库 | 抗癌临床化合物库 | 抗癌药物库 |
咗他莫司|||佐他莫司|||ABT-578|||A 179578|TargetMol
公司简介
TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。
成立日期 | (12年) |
注册资本 | 566.265100万人民币 |
员工人数 | 100-500人 |
年营业额 | ¥ 1亿以上 |
经营模式 | 贸易,工厂,试剂,定制,服务 |
主营行业 | 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务 |
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