依利格鲁司特|T3663|TargetMol

Eliglustat
491833-29-5

￥413 1mg 起订

￥868 5mg 起订

￥1280 10mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 依利格鲁司特

英文名称：: Eliglustat

CAS号：: 491833-29-5

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.71%

产品类别：: 抑制剂

货号：: T3663

Product Introduction

Bioactivity

Name	Eliglustat
Description	Eliglustat (Genz 99067) is an oral inhibitor of glucosylceramide synthase which is used in the therapy of type 1 Gaucher disease.
Cell Research	The inhibitory activity of Genz-112638 is determined indirectly by measuring its effect on the cell surface levels of the gangliosides GM1 and GM3 on either K562 or B16/F10 cells. GM1 levels on the K562 cells are determined by incubating the cells with increasing amounts of Genz-112638 (0.6-1000 nM) for 72 h after which the cells are harvested and stained using 10 μg of recombinant cholera toxin-FITC in 100 μL phosphate buffered saline (PBS) containing 0.5% bovine serum albumin (BSA) for 30 min on ice. Cells are ished, resuspended in PBS containing 0.5% BSA and the fluorescence quantitated[1].
Kinase Assay	Smo-binding assays are conducted with BODIPY-cyclopamine and Smo-overexpressing HEK 293T cells, using a CMVpromoter-based SV40 origin-containing expression construct for Smo-Myc3 (murine Smo containing three consecutive Myc epitopes at the C terminus). HEK 293T cells are seeded into eight-well chambered coverslips (80,000 cells/well) and cultured in DMEM containing 10% FBS, 100 U/mL penicillin, and 0.1 mg/mL streptomycin. The cells are cultured until they reached 55 to 65% confluency (14-18 h), after which they are transfected with the Smo-Myc3 expression construct and Transit-LT1. Twenty-four hours after transfection, the cells are washed with PBS and cultured in DMEM containing 0.5% FBS, 5 nM BODIPY-cyclopamine, and various concentrations of either cyclopamine or individual HPIs. After 30 min, 10 μM Hoescht 33342 is added to each well, and the HPIs are incubated with the cells for an additional 30 min. The cells are then washed two times with PBS buffer, once with phenol red-free DMEM containing 0.5% FBS, and immediately imaged using a DMI6000B compound microscope. Images are background-substracted using ImageJ software with a rolling ball size of 75 pixels, and BODIPY-cyclopamine intensity is then determined using Metamorph software. Circular regions with a diameter of 300 pixels are placed over regions containing uniformly confluent cells, and the pixel intensities of approximately 20 regions from four independent images is used to determine the average BODIPY-cyclopamine levels for each experimental condition[1].
In vitro	Eliglustat Tartrate啮齿类动物体内快速代谢,其体内半衰期在15-45分钟.对正常小鼠、大鼠、狗中通过静脉注射和口服途径给药（Eliglustat Tartrate）,脾脏、肾脏和肝脏中葡糖神经酰胺的含量显著下降.
In vivo	Eliglustat tartrate是葡萄糖神经酰胺合成酶的抑制剂,对该酶的抑制作用高度特异,对其他多种糖苷酶的抑制作用有限甚至没有抑制活性。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 74 mg/mL (182.9 mM) DMSO : 45 mg/mL (111.24 mM) H2O : < 1 mg/mL (insoluble or slightly soluble)
Keywords	inhibit \| Genz-99067 \| GENZ112638 \| Inhibitor \| Eliglustat \| GENZ 112638 \| Genz99067
Inhibitors Related	Alendronate sodium hydrate \| OU749 \| Entacapone \| Risedronic Acid \| 3-Methoxybenzamide \| Minodronic acid monohydrate \| Serotonin hydrochloride \| Flopropione \| Testosterone propionate \| Ibandronate sodium
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| Metabolism Compound Library \| EMA Approved Drug Library \| Anti-COVID-19 Compound Library \| FDA-Approved Drug Library \| Orally Active Compound Library \| Drug Repurposing Compound Library \| Human Metabolite Library

依利格鲁司特|||GENZ-112638|||Genz 99067|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
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