aladdin 阿拉丁 E413855 Eliglustat 491833-29-5 98%

中文名：Eliglustat

英文名：Eliglustat

纯度：Moligand™，≥98%

货号：E413855

Cas号：491833-29-5

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Eliglustat Eliglustat (GENZ-112638) inhibits glucosylceramide synthase(GCS) (IC50=20 nM in intact MDCK cells), thus reducing the load of glucosylceramide influx into the lysosome.

Targets

glucosylceramide synthase (In intact MDCK cells) 20 nM

In vitro

Eliglustat tartrate is designed and developed to inhibit glucosylceramide synthase, the enzyme that catalyzes the formation of glucosylceramide from UDP-glucose and ceramide.The inhibition of glucosylceramide synthase by eliglustat tartrate is highly specific. Eliglustat tartrate displays limited or no activity against a variety of glycosidases. Additionally, no inhibition of sucrase or maltase is observed at drug concentrations up to 10 μM.

In vivo

Preclinical studies in normal mice, rats and dogs with i.v. and oral administration demonstrates significant dose-related decreases in spleen, kidney and liver glucosylceramide content, consistent with prior observations with the palmitoyl homologue.In rodents, Genz-112638 is rapidly metabolized with a half-life of 15–45 minutes.

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