ZZW-115|T9429|TargetMol

ZZW-115
801991-87-7

￥1870 1mg 起订

￥2790 2mg 起订

￥4650 5mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: ZZW-115

英文名称：: ZZW-115

CAS号：: 801991-87-7

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T9429

Product Introduction

Bioactivity

名称	ZZW-115
描述	ZZW-115 is a potent NUPR1 inhibitor with a Kd of 2.1 μM. ZZW-115 is a derivative of Trifluoperazine (TFP). ZZW-115 shows a dose-dependent tumor regression with no neurological side effects and induces cell death mainly by necroptosis and apoptosis[1] [2].
体外活性	ZZW-115 (0.1-33 μM; 72 hours) effectively kills cancer cells, with an IC 50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14) [1]. ZZW-115 (0-100 μM; 24-72 hours) is efficient to kill these tumor cells with an IC 50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells) [1]. ZZW-115 induces pancreatic cell death by necrosis and apoptosis. ZZW-115 treatment induces a decrease in ATP production and induces a ROS overproduction [1]. LDH release is significantly higher in ZZW-115-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b, and HN14 cells) than in control cells in a concentration-dependent manner. Similarly, caspase 3/7 activity is also greater in ZZW-115-treated cells. These experiments demonstrated that ZZW-115 exerted both pronecrotic and proapoptotic effects [1]. Cell Viability Assay [1] Cell Line: ANOR cells, MiaPaCa-2, 02-063, 01008, LIPC, 02136, HN01,01046, AOIPC, Foie8b, HN14 cells Concentration: 0.1- 33 μM Incubation Time: 72 hours Result: Was efficient in killing cancer cells, with an IC 50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14). Cell Proliferation Assay [1] Cell Line: U87, A375, U2OS, SaOS-2, HT29, SK-CO-1, LS174T, H1299 and H358, HepG2, PC3, THP-1, Daudi, Jurkat and MDA-MB-231 cells Concentration: 0-100 μM Incubation Time: 24 or 72 hours Result: Was efficient to kill these tumor cells with an IC 50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).
体内活性	ZZW-115 (0.5-5 mg/kg; injection; daily for 30 days) inhibits the pancreatic xenografted tumors growth [1]. ZZW-115 (5 mg/kg for 30 days; immunocompetent C57BL/6 mice were orthotopically implanted with Panc02 cells) treatment shows the tumor size is almost unmeasurable in some cases [1]. Animal Model: NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells [1] Dosage: 5, 2.5, 1.0, or 0.5 mg/kg Administration: Injection, daily for 30 days Result: When the mice were injected with 5 mg/kg ZZW-115, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment.
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
关键字	ZZW-115 \| ZZW115 \| ZZW 115
相关产品	Sodium citrate \| L-Methionine \| Gefitinib \| Cysteamine hydrochloride \| Alginic acid \| Metronidazole \| Dextran sulfate sodium salt (MW 5000) \| Citric Acid Triammonium \| Stavudine \| Cystamine dihydrochloride \| L-Ascorbic acid sodium salt \| Sodium 4-phenylbutyrate

ZZW-115|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(13年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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