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网站主页 化工产品目录 生物化工 抑制剂 血管生成(Angiogenesis) FLT3 抑制剂 TCS 359 化合物 TCS 359
  • 化合物 TCS 359|T6138|TargetMol

化合物 TCS 359|T6138|TargetMol

TCS 359
301305-73-7
￥1568 50mg 起订
￥498 10mg 起订
上海 更新日期：2024-09-29

TargetMol中国（陶术生物）

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联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 TCS 359
英文名称：
TCS 359
CAS号：
301305-73-7
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
99.31%
产品类别：
抑制剂
货号：
T6138

Product Introduction

Bioactivity

NameTCS 359
DescriptionTCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM.
Cell ResearchMV4-11 cells are plated at 10,000 cells per well in 100 μL of in RPMI media containing penn/strep, 10% FBS, and 0.2 ng/mL GM-CSF. Compound dilutions or 0.1% DMSO (vehicle control) is added to cells and the cells are allowed to grow for 72 h at standard cell growth conditions. To measure total cell growth, an equal volume of CellTiterGlo reagent is added to each well and luminescence is quantified. Total cell growth is quantified as the difference in luminescent counts of cell number at Day 0 compared to total cell number at Day 3 (72 h of growth and/or compound treatment). All IC50 values are calculated in GraphPadPrism using non-linear regression analysis with a multiparameter (variable slope) equation.(Only for Reference)
Kinase AssayAffinity determination: To determine the activity of the compounds of the present invention in an in vitro kinase assay, inhibition of the isolated kinase domain of the human FLT3 receptor is performed using the following fluorescence polarization (FP) protocol. The FLT3 fluorescence polarization assay utilizes the fluorescein-labeled phosphopeptide and the anti-phosphotyrosine antibody included in the Panvera Phospho-Tyrosine Kinase Kit. The FLT3 kinase reaction is incubated at room temperature for 30 min under the following conditions: 10 nM FLT3 571-993, 20μg/mL poly Glu4Tyr, 150 μM ATP, 5 mM MgCl2, and 1% compound in DMSO. The kinase reaction is stopped with the addition of EDTA. The fluorescein-labeled phosphopeptide and the anti-phosphotyrosine antibody are added and incubated for 30 min at room temperature and polarization is read.
In vitroTCS 359，一种2-acylaminothiophene-3-carboxamide，是一种高效的FLT3抑制剂，其IC50为42 nM。它对MV4-11细胞增殖的抑制作用的IC50为340 nM，且对FLT3的选择性较其他激酶篇幅的高。[1]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 10.8 mg/mL (30 mM)
KeywordsFLT3 | inhibit | Fms like tyrosine kinase 3 | TCS 359 | TCS-359 | TCS359 | Cluster of differentiation antigen 135 | Inhibitor | CD135
Inhibitors RelatedSGI-1776 | Gilteritinib | KW-2449 | Sorafenib tosylate | Sunitinib Malate | 4SC-203 | Tandutinib | Nintedanib | Sorafenib | Pexidartinib | Fedratinib | UNC2025
Related Compound LibrariesInhibitor Library | Anti-Parkinson's Disease Compound Library | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Highly Selective Inhibitor Library | NO PAINS Compound Library | Anti-Neurodegenerative Disease Compound Library | Tyrosine Kinase Inhibitor Library
FLT3 Inhibitor|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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