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网站主页 Thalidomide-O-amido-C4-NH2 hydrochloride 化合物 Thalidomide-O-amido-C4-NH2 hydrochloride
  • 化合物 Thalidomide-O-amido-C4-NH2 hydrochloride|T18815|TargetMol

化合物 Thalidomide-O-amido-C4-NH2 hydrochloride|T18815|TargetMol

Thalidomide-O-amido-C4-NH2 hydrochloride
2245697-86-1
297 2mg 起订
上海 更新日期:2024-09-29

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产品详情:

中文名称:
化合物 Thalidomide-O-amido-C4-NH2 hydrochloride
英文名称:
Thalidomide-O-amido-C4-NH2 hydrochloride
CAS号:
2245697-86-1
品牌:
TargetMol
产地:
美国
保存条件:
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
产品类别:
抑制剂
货号:
T18815

Product Introduction

Bioactivity

名称Thalidomide-O-amido-C4-NH2 hydrochloride
描述Thalidomide-O-amido-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Thalidomide with a linker. It is commonly employed in the synthesis of PROTACs[1].
体外活性Thalidomide-O-amido-C4-NH2 is an amine intermediate (Compound 41), which can be used as is a heterobifunctional PROTAC BET degrader. The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT members, are epigenetic 'readers” and play a key role in the regulation of gene transcription. BET proteins are considered to be attractive therapeutic targets for cancer and other human diseases. Recently, heterobifunctional small-molecule BET degraders have been designed based upon the proteolysis targeting chimera (PROTAC) concept to induce BET protein degradation[1]. Thalidomide-O-amido-C4-NH2 is a degron-linker (refer to Compound DL6-TL). Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein (s)[2].
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
关键字Thalidomide-O-amido-C4-NH2 Hydrochloride | ThalidomideOamidoC4NH2 hydrochloride | Thalidomide-O-amido-C-4-NH2 hydrochloride | Thalidomide O amido C4 NH2 hydrochloride
Thalidomide-O-amido-C4-NH2 hydrochloride|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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