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网站主页 化工产品目录 生物化工 抑制剂 内分泌及激素(Endocrinology & Hormones) Estrogen/progestogen Receptor 调节剂 盐酸巴多昔芬 Bazedoxifene 盐酸盐
  • Bazedoxifene 盐酸盐|T6404|TargetMol

Bazedoxifene 盐酸盐|T6404|TargetMol

Bazedoxifene hydrochloride
198480-56-7
￥492 1mg 起订
￥1270 5mg 起订
￥2300 10mg 起订
上海 更新日期：2024-12-12

TargetMol中国（陶术生物）

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联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
Bazedoxifene 盐酸盐
英文名称：
Bazedoxifene hydrochloride
CAS号：
198480-56-7
品牌：
TargetMol
产地：
美国
保存条件：
store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
98.74%
产品类别：
抑制剂
货号：
T6404

Product Introduction

Bioactivity

名称Bazedoxifene hydrochloride
描述Bazedoxifene hydrochloride (TSE 424 hydrochloride) is an orally active, selective, and potent estrogen receptor modulator (SERM) that crosses the blood-brain barrier and is an inhibitor of IL-6/GP130 protein interactions with high affinity for ERα and ERβ. It has a high affinity for ERα and ERβ and can be used to study postmenopausal osteoporosis and vasodilator-related diseases.
细胞实验For the proliferation assay, cells are plated at 20,000 cells/well in a 24-well plate in DMEM/F12 (50:50) (phenol red-free) with 10% charcoal/dextran-treated FBS and 1 × GlutaMAX-1. After overnight incubation, the medium is aspirated and treatments in DMEM/F12 (50:50) (phenol red-free) with 2% charcoal/dextran-treated FBS and 1 × GlutaMAX-1 are added to the wells. Each plate has a vehicle (baseline proliferation) and treatments. Treatments included 10 pM 17β-estradiol determined to be the EC80 for 17β-estradiol and 17β-estradiol in combination with six concentrations of BZA. Treatments from d 1 are renewed on d 3 and d 6 by aspirating medium from wells and replacing with fresh medium and treatments. On d 7, cells are detached from the plate using trypsin-EDTA and counted using a Multisizer II.(Only for Reference)
激酶实验Ligand binding competition experiments: Test compounds are initially solubilized in DMSO and the final concentration of DMSO in the binding assay is ≤ 1%. Eight dilutions of each test compound are used as an unlabelled competitor for [3H]17β-estradiol. Typically, a set of compound dilutions would be tested simultaneously on human, rat and mouse ER-α and ER-β. The results are plotted as measured DPM vs. concentration of test compound. For dose-response curve fitting, a four parameter logistic model on the transformed, weighted data are fit and the IC50 is defined as the concentration of compound decreasing maximum [3H]estradiol binding by 50%. For active compounds, the IC50 is determined at least three times. It should be noted that IC50 values are not direct measures of a ligand's affinity for the receptor. Rather, they can only be compared as relative values, in this case to 17β-estradiol.
体外活性在 AsPC-1 细胞中，Bazedoxifene hydrochloride（10 μM-20 μM；2 小时）能够抑制由 IL-6、IL-11 或 OSM（各50 ng/mL）诱导的 STAT3 磷酸化[2]。
体内活性在 6 周龄的雌性无胸腺裸鼠中，Bazedoxifene hydrochloride（剂量为5 mg/kg；通过口服灌胃，每日一次，持续 18 天）被用于抑制胰腺癌异种移植瘤的生长，并在肿瘤细胞中诱导凋亡[2]。
存储条件store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度H2O : <1 mg/mL
Ethanol : <1 mg/mL
DMSO : 93 mg/mL (183.4 mM)
关键字TSE-424 | TSE424 | TSE 424 | STAT3 | SERM | selective | receptor | protein-protein | modulator | interactions | IL-6/GP130 | Estrogen Receptor/ERR | estrogen | ERβ | ERα | Bazedoxifene HCl | Bazedoxifene
相关产品Estradiol | Sodium Thiocyanate | Amlexanox | Diallyl disulfide | Melatonin | Mifepristone | Inosine pranobex | Dexamethasone | Ethisterone | Tamoxifen | Kaempferol | Disulfiram
相关库抑制剂库 | 经典已知活性库 | 抗癌化合物库 | 已知活性化合物库 | FDA上市及药典收录分子库 | 上市药物库 | FDA 上市药物库 | 免疫/炎症分子化合物库 | 口服活性化合物库 | 药物功能重定位化合物库
WAY 140424 hydrochloride|||TSE-424 hydrochloride|||TSE424 hydrochloride|||TSE 424 hydrochloride|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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