化合物 Roniciclib|T16784|TargetMol

Roniciclib
1223498-69-8

￥567 1mg 起订

￥1130 5mg 起订

￥1820 10mg 起订

上海更新日期：2025-11-17

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产品详情:

中文名称：: 化合物 Roniciclib

英文名称：: Roniciclib

CAS号：: 1223498-69-8

品牌：: TargetMol

产地：: 美国

保存条件：: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 98.63%

产品类别：: 抑制剂

货号：: T16784

Product Introduction

Bioactivity

名称	Roniciclib
描述	Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.
体外活性	Roniciclib inhibits the kinase activity of the cell-cycle CDKs CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclinD (IC50: 7, 9, and 11 nM, respectively). Roniciclibeffectively inhibits the proliferation of various human and murine tumor cell lines with a very balanced profile (mean IC50 on human tumor cells: 16 nM). The transcriptional CDKs CDK9/cyclin T1 and CDK7/cyclin H/MAT1 are inhibited in a similar range (5 and 25 nM) [1][2].
体内活性	Roniciclib has low blood clearance rates in mouse, rat, and dog (0.51, 0.78, and 0.50 Lh-1kg-1, respectively). Roniciclib strongly inhibits the growth of HeLa-MaTu tumors that have been grown to a size of approximately 50mm2 before the start of treatment. Roniciclib (1.5 and 1 mg/kg) treatment slow tumor growth to T/C values of 0.15 and 0.62, respectively. The addition of Roniciclib to cisplatin causes a strong tumor growth inhibition with T/C values of 0.01 (1.0 mg/kg Roniciclib) and -0.02 (1.5 mg/kg Roniciclib) [1][2].
存储条件	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 249 mg/mL (578.48 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (11.62 mM), Sonication is recommended.
关键字	Roniciclib \| Inhibitor \| inhibit \| Cyclin dependent kinase \| CDK9/cyclinT1 \| CDK9/cyclin T1 \| CDK7/Cyclin H/MAT1 \| CDK4/CyclinD \| CDK4/cyclin D \| CDK3/cyclinE \| CDK2/cyclinE \| CDK1/CyclinB \| Cdk1/cyclin B \| CDK \| BAY-1000394 \| BAY1000394
相关产品	Sodium Oxamate \| Ribociclib \| Palbociclib monohydrochloride \| Abemaciclib methanesulfonate \| Abemaciclib \| CASIN \| Olomoucine \| Palbociclib \| GW 441756 \| Dinaciclib \| Ro-3306 \| GSK 3 Inhibitor IX
相关库	抑制剂库 \| 经典已知活性库 \| 抗癌化合物库 \| 已知活性化合物库 \| 细胞周期化合物库 \| 临床失败化合物库 \| 含氟化合物库 \| 口服活性化合物库 \| 药物功能重定位化合物库 \| 抗癌药物库

BAY 1000394|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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