福他替尼二钠盐|T2605|TargetMol

Fostamatinib Disodium
1025687-58-4

￥272 1mg 起订

￥415 2mg 起订

￥828 5mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 福他替尼二钠盐

英文名称：: Fostamatinib Disodium

CAS号：: 1025687-58-4

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 98.95%

产品类别：: 抑制剂

货号：: T2605

Product Introduction

Bioactivity

名称	Fostamatinib Disodium
描述	Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.
细胞实验	Cells are exposed to increasing concentrations of R406 (in vitro active form of R935788) for 48 hours. The percentage of apoptotic cells is determined by double staining with propidium iodide (PI) and annexin-A5–FITC conjugate. Ki-67 staining is performed with the FITC mouse anti–Ki-67 set. Samples are analyzed on a FACSCalibur flow cytometer with CellQuest Version 3.3 software. (Only for Reference)
激酶实验	In vitro fluorescence polarization kinase assays: R406 (in vitro active form of R935788) is serially diluted in DMSO and then diluted to 1% DMSO in kinase buffer (20 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM MnCl2, 1 mM DTT, 0.1 mg/mL acetylated BGG). ATP and substrate in kinase buffer are added at room temperature, resulting in a final DMSO concentration on 0.2%. The kinase reactions are performed in a final volume of 20 μL containing 5 μM HS1 peptide substrate and 4 μM ATP and started by addition of 0.125 ng of Syk in kinase buffer. The reaction is allowed to proceed for 40 minutes at room temperature. The reaction is stopped by the addition of 20 μL of PTK quench mix containing EDTA/anti-phosphotyrosine antibody (1× final)/fluorescent phosphopeptide tracer (0.5× final) diluted in FP Dilution Buffer. The plate is incubated for 30 minutes in the dark at room temperature and then read on a Polarion fluorescence polarization plate reader. Data is converted to determine the amount of phosphopeptide present using a calibration curve generated by competition with the phosphopeptide competitor provided in the Tyrosine Kinase Assay Kit. For IC50 determination, R406 is tested at eleven concentrations in duplicate and curve-fitting is performed by non-linear regression analysis using Prism GraphPad Software.
体外活性	在小鼠肿瘤模型中,每天R935788（80 mg/kg）能够有效抑制 TCL1-002, TCL1-551 和 TCL1-870肿瘤生长.在Eμ-TCL1转基因小鼠中,R935788通过阻止抗原依赖性B细胞受体的信号,抑制白血病细胞增殖和存活.
体内活性	在多种弥散性大B细胞淋巴瘤细胞系中（EC50=0.8-8.1 μM）,R406降低BLNK, Akt, GSK-3, FOXO和ERK 磷酸化,抑制细胞增殖。
存储条件	keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 50 mg/mL (80.07 mM)
关键字	FLT3 \| Fms like tyrosine kinase 3 \| Spleen tyrosine kinase \| CD135 \| R-788 \| Fostamatinib \| Fostamatinib Disodium \| Syk \| Cluster of differentiation antigen 135 \| inhibit \| R788 \| R 788 \| R788 (Fostamatinib) \| Inhibitor
相关产品	SGI-1776 \| Gilteritinib \| KW-2449 \| Sorafenib tosylate \| Sunitinib Malate \| ANTHRAQUINONE-2-CARBOXYLIC ACID \| 4SC-203 \| Nintedanib \| Sorafenib \| Pexidartinib \| Fedratinib \| UNC2025
相关库	抑制剂库 \| 经典已知活性库 \| 抗癌上市药物库 \| 已知活性化合物库 \| EMA 上市药物库 \| 激酶抑制剂库 \| FDA 上市药物库 \| 抗病毒库 \| 酪氨酸激酶分子库 \| FDA 上市激酶抑制剂库 \| 药物功能重定位化合物库 \| 抗癌临床化合物库

福他替尼二钠盐|||Tamatinib Fosdium|||R788(Disodium)|||R788 Disodium|||R788 (Fostamatinib) Disodium|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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