化合物 Lith-O-Asp|T11858|TargetMol

Lith-O-Asp
881179-02-8

￥3630 2mg 起订

￥4570 5mg 起订

￥10600 25mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 Lith-O-Asp

英文名称：: Lith-O-Asp

CAS号：: 881179-02-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T11858

Product Introduction

Bioactivity

名称	Lith-O-Asp
描述	Lith-O-Asp is a sialytransferase (ST) inhibitor,(IC50s:12-37 μM).
体外活性	The results indicates that Lith-O-Asp decreased the activity of both a-2,3- and a-2,6-sialyltransferases, and thus inhibit the transfer of sialic acids to the targeted glycoproteins[1].The results indicate that Lith-O-Asp shows no apparent growth inhibition effect toward different cancer cell lines at the tested doses of 10, 30, and 60 μM.?By in vitro activity assay, it is revealed that the ability of Lith-O-Asp to inhibit the activities of ST3Gal I, ST3Gal III, and ST6GalI.?The IC50 values ranged from 12 to 37 μM.?Flow cytometry shows a significant decrease in the expression of cell surface a-2,3- and a-2,6-sialylated antigens.
体内活性	A significant amount of secondary metastatic cancer cells are observed in lung tissues of DMSO control mice detected using IVIS in vivo imaging system after 26 days of fat pad inoculation.?However, Lith-O-Asp–treated mice show fewer lung metastases.?All DMSO-treated mice confirm secondary lung metastasis, but only 3 of 8 Lith-O-Asp-treated mice show lung metastasis.?Average tumor nodules per mouse are 11±9 nodules in DMSO-treated group, and 2±4 nodules in Lith-O-Asp-treated group.?Additionally, significantly stronger 4T1-Luc illumination signals are shown in control mice than in those injected with Lith-O-Asp-treated cancer cells on days 7 and 9[1].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 106 mg/mL (215.6 mM), Sonication is recommended.
关键字	ST \| Lith-O-Asp \| LithOAsp \| Lith O Asp
相关产品	Risedronate Sodium \| CBHcy \| Rosmarinic acid \| OU749 \| Entacapone \| Risedronic Acid \| 3-Methoxybenzamide \| Serotonin hydrochloride \| Flopropione \| Testosterone propionate \| Alendronate sodium trihydrate \| Ibandronate sodium

Lith-O-Asp|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(13年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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