881179-02-8
基本信息
Cholan-24-oic acid, 3-[(2S)-2-amino-3-carboxy-1-oxopropoxy]-, (3α,5β)-
物理化学性质
| 熔点 | 208-209 °C |
| 沸点 | 635.0±45.0 °C(Predicted) |
| 密度 | 1.19±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | DMSO : ≥ 106 mg/mL (215.60 mM) |
| 酸度系数(pKa) | 3.43±0.19(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
881179-02-8价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-112415 | Lith-O-Asp | 881179-02-8 | 1 mg | 2200元 |
| 2025/02/08 | HY-112415 | 881179-02-8 Lith-O-Asp | 881179-02-8 | 5mg | 5500元 |
| 2025/02/08 | HY-112415 | Lith-O-Asp | 881179-02-8 | 10 mM * 1 mLin DMSO | 6050元 |
常见问题列表
IC50: 12-37 μM (ST).
The results indicate that Lith-O-Asp shows no apparent growth inhibition effect toward different cancer cell lines at the tested doses of 10, 30, and 60 μM. By in vitro activity assay, it is revealed that the ability of Lith-O-Asp to inhibit the activities of ST3Gal I, ST3Gal III, and ST6GalI. The IC 50 values ranged from 12 to 37 μM. Flow cytometry shows a significant decrease in the expression of cell surface a-2,3- and a-2,6-sialylated antigens on The results indicates that Lith-O-Asp decreased the activity of both a-2,3- and a-2,6-sialyltransferases, and thus inhibit the transfer of sialic acids to the targeted glycoproteins.
A significant amount of secondary metastatic cancer cells are observed in lung tissues of DMSO control mice detected using IVIS in vivo imaging system after 26 days of fat pad inoculation. However, Lith-O-Asp–treated mice show fewer lung metastases. All DMSO-treated mice confirm secondary lung metastasis, but only 3 of 8 Lith-O-Asp-treated mice show lung metastasis. Average tumor nodules per mouse are 11±9 nodules in DMSO-treated group, and 2±4 nodules in Lith-O-Asp-treated group. Additionally, significantly stronger 4T1-Luc illumination signals are shown in control mice than in those injected with Lith-O-Asp-treated cancer cells on days 7 and 9.