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  • 达卢生坦|T5458|TargetMol

达卢生坦|T5458|TargetMol

Darusentan
171714-84-4
￥397 1mg 起订
￥595 2mg 起订
￥996 5mg 起订
上海 更新日期：2024-12-12

TargetMol中国（陶术生物）

VIP3年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
达卢生坦
英文名称：
Darusentan
CAS号：
171714-84-4
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
98.72%
产品类别：
抑制剂
货号：
T5458

Product Introduction

Bioactivity

名称Darusentan
描述Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries
细胞实验Briefly, isolated rat aortic smooth muscle cells were incubated overnight in complete media in a 96-well microplate at a density of 50 000 cells/well. The next day, cells were starved for 24 h in 0% serum conditions. Following starvation, medium was removed and cells were dosed with 20 μL of increasing concentrations of darusentan (0, 0.001, 0.01, 0.1, 1, and 10 μmol/L) made in stimulation buffer containing 50 mmol/L LiCl. Cells were incubated at 37 °C, 5% CO2 for 30 min before the addition of 20 μL of ET-1 in dose-response fashion. Cells were incubated in the presence or absence of darusentan and ET-1 at 37 °C, 5% CO2 for 60 min. Following this incubation, cells were lysed using 20 μL of 2.5% lysis solution for 30 min and lysates were transferred to a 96-well microplate pre-coated with goat anti-mouse IgG. After transfer into the ELISA plate, kit-supplied IP1-horseradish peroxidase (HRP) conjugate and anti-IP1 mAb were added to the lysates. Assays were incubated for 3 h at room temperature on a platform shaker. Assay plates were then washed 6 times with 1× ELISA wash solution (250 μL/well) before the addition of HRP substrate TMB (3, 3', 5, 5'-tetramethylbenzidine). After 20 min, the reaction was stopped and the optical density (OD) was measured at 450 nm with a correction of 620 nm. Measurements were performed in triplicate.
体外活性Darusentan 抑制与促收缩活动有关的内皮素诱导信号，并且是大、小动脉血管收缩强效抑制剂。
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 125 mg/mL (304.57 mM)
H2O : Insoluble
关键字vascular | ET-A | Endothelin Receptor | rat | muscle | Inhibitor | Lu 135252 | receptor | aortic | endothelin | inhibit | smooth | RAVSMs | Darusentan | Lu135252
相关产品Clazosentan | Aprocitentan | Edonentan | Sparsentan | Macitentan | Sulfisoxazole | BMS 182874 | BMS 182874 hydrochloride | Ambrisentan | Bosentan | Sitaxsentan sodium | Sitaxsentan
相关库抑制剂库 | 经典已知活性库 | 已知活性化合物库 | NO PAINS 化合物库 | GPCR靶点分子库 | 膜蛋白靶向化合物库 | 疼痛相关化合物库 | 药物功能重定位化合物库 | 抗癌临床化合物库 | 抗癌药物库
达卢生坦|||Lu-135252|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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